Effect of epinephrine deficiency on cold tolerance and on brown adipose tissue
| Autor: | Maria Joachim, Michelle A. Mulcahey, Rana Sharara-Chami, Joseph A. Majzoub, Steven N. Ebert |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Epinephrine Adipose tissue Thyroid Function Tests Biology Biochemistry Ion Channels Mitochondrial Proteins Mice chemistry.chemical_compound Endocrinology Adipose Tissue Brown Internal medicine Brown adipose tissue medicine Animals Molecular Biology Uncoupling Protein 1 Mice Knockout Phenylethanolamine N-Methyltransferase Temperature Hypothermia Lipid Metabolism Adaptation Physiological Thermogenin Cold Temperature Phenylethanolamine medicine.anatomical_structure Gene Expression Regulation chemistry Temperature homeostasis Triiodothyronine medicine.symptom Thermogenesis Body Temperature Regulation Transcription Factors medicine.drug |
| Zdroj: | Molecular and Cellular Endocrinology. 328:34-39 |
| ISSN: | 0303-7207 |
| DOI: | 10.1016/j.mce.2010.06.019 |
| Popis: | Catecholamines are involved in thermogenesis. We investigated the specific role of epinephrine in regulation of temperature homeostasis in mice. We subjected adult wildtype (WT) and phenylethanolamine N-methyl transferase knock out mice (Pnmt(-/-)) lacking epinephrine to cold for 24h. Body temperature and thyroid hormone levels were not different between WT and Pnmt(-/-) mice. Although temperature was normal in Pnmt(-/-) mice, the brown fat response to cold was abnormal with no increase in Ucp-1 or Pgc-1alpha mRNA levels (but with an exaggerated cold-induced lipid loss from the tissue). Our results show that epinephrine may have a role in brown fat mitochondrial uncoupling through regulation of Ucp-1 and Pgc-1alpha, although this is not required to maintain a normal temperature during acute cold exposure. We conclude that epinephrine may have an important role in induction of Ucp-1 and Pgc-1alpha gene expression during cold stress. |
| Databáze: | OpenAIRE |
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