Involvement of the rat prefrontal cortex in a delayed reinforcement operant task
| Autor: | Yoshinori Izaki, Tatsuo Akema, Sei-etsu Fujiwara |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
Central nervous system Action Potentials Prefrontal Cortex Hippocampus Neuropsychological Tests Hippocampal formation chemistry.chemical_compound Cognition Memory Neural Pathways Reaction Time medicine Animals Premovement neuronal activity Operant conditioning Rats Wistar Prefrontal cortex Reinforcement GABA Agonists Neurons Behavior Animal Muscimol General Neuroscience Denervation Rats Memory Short-Term medicine.anatomical_structure nervous system chemistry Conditioning Operant Psychology Reinforcement Psychology Neuroscience |
| Zdroj: | NeuroReport. 18:1687-1690 |
| ISSN: | 0959-4965 |
| Popis: | To determine whether the rat medial prefrontal cortex (PFC) is involved in delayed reinforcement operant behavior, we studied the effects of transient inactivation of the medial PFC (or the hippocampus as a control) during a delayed reinforcement lever-press task. We demonstrated the involvement of the PFC in this task: PFC inactivation but not hippocampal inactivation significantly impaired performance. In a separate experiment, we also recorded the prefrontal multiple unit activities during the task to determine the roles of the PFC in detail. Neuronal activity decreased during the delay period, suggesting that this decrease plays a role in delayed reinforcement operant behavior. |
| Databáze: | OpenAIRE |
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