A Brief Review of Brain's Blood Flow-Metabolism Coupling and Pressure Autoregulation
| Autor: | Eleftherios Spartalis, Stefanos Korfias, Damianos P. Sakas, Panayiotis Patrikelis, Konstantinos M. Themistoklis, Konstantinos Melanis, Themistoklis Papasilekas |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Subarachnoid hemorrhage
Traumatic brain injury Blood Pressure Cerebral autoregulation 03 medical and health sciences Cerebral circulation 0302 clinical medicine medicine Homeostasis Humans Autoregulation Stroke business.industry Hemodynamics Brain 030208 emergency & critical care medicine Blood flow Human brain medicine.disease medicine.anatomical_structure Cerebrovascular Circulation Surgery Neurology (clinical) business Energy Metabolism Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Journal of neurological surgery. Part A, Central European neurosurgery. 82(3) |
| ISSN: | 2193-6323 |
| Popis: | Background The human brain, depending on aerobic glycolysis to cover its metabolic needs and having no energy reserves whatsoever, relies on a constant and closely regulated blood supply to maintain its structural and functional integrity. Cerebral autoregulation, that is, the brain's intrinsic ability to regulate its own blood flow independently from the systemic blood pressure and cardiac output, is an important physiological mechanism that offers protection from hypoperfusion injury. Discussion Two major independent mechanisms are known to be involved in cerebral autoregulation: (1) flow–metabolism coupling and (2) myogenic responses of cerebral blood vessels to changes in transmural/arterial pressure. A third, less prominent component of cerebral autoregulation comes in the form of neurogenic influences on cerebral vasculature. Conclusion Although fragmentation of cerebral autoregulation in separate and distinct from each other mechanisms is somewhat arbitrary, such a scheme is useful for reasons of simplification and to better understand their overall effect. Comprehension of cerebral autoregulation is imperative for clinicians in order for them to mitigate consequences of its impairment in the context of traumatic brain injury, subarachnoid hemorrhage, stroke, or other pathological conditions. |
| Databáze: | OpenAIRE |
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