Decreased serum level of NGF in alcohol-dependent patients with declined executive function
| Autor: | Youngsun Ra, Hwallip Bae, Changwoo Han, Daijin Kim |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Neuropsychiatric Disease and Treatment biology business.industry alcohol dependence Trail Making Test Alcohol dependence Neuropsychology medicine.anatomical_structure Nerve growth factor Endocrinology nervous system executive function Neurotrophic factors Internal medicine nerve-growth factor medicine biology.protein Neuron Cognitive decline trail-making test Psychiatry business Neurotrophin Original Research |
| Zdroj: | Neuropsychiatric Disease and Treatment |
| ISSN: | 1178-2021 1176-6328 |
| Popis: | Hwallip Bae,1 Youngsun Ra,1 Changwoo Han,2 Dai-Jin Kim3 1Department of Psychiatry, Myongji Hospital, Goyang, 2Department ofPsychiatry, Keyo Hospital, Uiwang, 3Department of Psychiatry, Seoul StMary’s Hospital, College ofMedicine, Catholic University ofKorea, Seoul, South Korea Abstract: The role of neurotrophic factors has been highlighted as a cause of decline in the cognitive function of alcohol-dependent patients. It is known that nerve-growth factor (NGF), one of the neurotrophins, is related to the growth and differentiation of nerve cells, as well as to a decline in cognitive function. The purpose of this study was to investigate the relationship between decreased NGF levels and cognitive decline in alcohol-dependent patients. The serum concentration of NGF was measured in 38patients with chronic alcohol dependence, and several neuropsychological tests were also performed for cognitive function assessment. The results indicated a significant correlation between serum NGF level and the trail-making test part B, which evaluates executive function, but did not show a significant correlation with other cognitive function tests. An increased serum level of NGF was associated with a decreased completion time in the trail-making test B, and this finding indicates that a high serum level of NGF is related to greater executive function. This finding may imply a protective role of NGF in preventing neuron damage among patients with alcohol dependence. Larger controlled studies will be necessary in the future to investigate this issue further. Keywords: nerve-growth factor, alcohol dependence, executive function, trail-making test |
| Databáze: | OpenAIRE |
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