Networks in the Field of Tourette Syndrome
| Autor: | Alexander Kleimaker, Maximilian Kleimaker, Amelie Behm, Anne Weissbach, Tobias Bäumer, Christian Beste, Veit Roessner, Alexander Münchau |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Gilles de la Tourette syndrome
European Multicenter Tics in Children Studies Tics the Tourette Association of America Review Tourette syndrome lcsh:RC346-429 research networks 03 medical and health sciences 0302 clinical medicine Neurodevelopmental disorder Neuroimaging Multidisciplinary approach medicine Attention deficit hyperactivity disorder lcsh:Neurology. Diseases of the nervous system European Society for The Study of Tourette Syndrome medicine.disease 030227 psychiatry Neurology Etiology Neurology (clinical) Psychology 030217 neurology & neurosurgery Mirroring Clinical psychology |
| Zdroj: | Frontiers in Neurology Frontiers in Neurology, Vol 12 (2021) |
| ISSN: | 1664-2295 |
| Popis: | Gilles de la Tourette syndrome (TS) is a neuropsychiatric neurodevelopmental disorder with the cardinal clinical features of motor and phonic tics. Clinical phenomenology can be complex since, besides tics, there are other features including premonitory urges preceding tics, pali-, echo-, and coprophenomena, hypersensitivity to external stimuli, and symptom dependency on stress, attention, and other less well-defined factors. Also, the rate of comorbidities, particularly attention deficit hyperactivity disorder and obsessive-compulsive disorder, is high. Mirroring the complexities of the clinical course and phenomenology, pathophysiological findings are very diverse, and etiology is disputed. It has become clear, though, that abnormalities in the basal ganglia and their connections with cortical areas are key for the understanding of the pathophysiology and as regards etiology, genetic factors are crucial. Against this background, both adequate clinical management of TS and TS-related research require multidisciplinary preferably international cooperation in larger groups or networks to address the multiple facets of this disorder and yield valid and useful data. In particular, large numbers of patients are needed for brain imaging and genetic studies. To meet these requirements, a number of networks and groups in the field of TS have developed over the years creating an efficient, lively, and supportive international research community. In this review, we will provide an overview of these groups and networks. |
| Databáze: | OpenAIRE |
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