Appetite-regulating hormone trajectories and relationships with fat mass development in term-born infants during the first 6 months of life
| Autor: | Gerthe F. Kerkhof, Kirsten S. de Fluiter, Anita C. S. Hokken-Koelega, Leonie C. van Vark-van der Zee, Inge A L P van Beijsterveldt, Monique T. Mulder, Laura M Breij, Marieke Abrahamse-Berkeveld |
|---|---|
| Přispěvatelé: | Pediatrics, Internal Medicine |
| Rok vydání: | 2021 |
| Předmět: |
Leptin
medicine.medical_specialty Appetite Medicine (miscellaneous) Body composition Fat mass Internal medicine Orexigenic medicine Humans Peptide YY Appetite-Regulating Hormone Adiposity Nutrition and Dietetics Milk Human business.industry digestive oral and skin physiology Infant Newborn Infant Original Contribution Appetite-regulating hormones Ghrelin Early life Endocrinology Female Macronutrients business Infants hormones hormone substitutes and hormone antagonists medicine.drug Hormone |
| Zdroj: | European Journal of Nutrition European Journal of Nutrition, 60(7), 3717-3725. D. Steinkopff-Verlag |
| ISSN: | 1436-6215 1436-6207 |
| DOI: | 10.1007/s00394-021-02533-z |
| Popis: | Background The first 6 months of life are a critical window for adiposity programming. Appetite-regulating hormones (ARH) are involved in food intake regulation and might, therefore, play a role in adiposity programming. Studies examining ARH in early life are limited. Purpose To investigate ghrelin, peptide YY (PYY) and leptin until 6 months and associations with fat mass percentage (FM%), infant feeding and human milk macronutrients. Procedures In 297 term-born infants (Sophia Pluto Cohort), ghrelin (acylated), PYY and leptin were determined at 3 and 6 months, with FM% measurement by PEAPOD. Exclusive breastfeeding (BF) was classified as BF ≥ 3 months. Human milk macronutrients were analyzed (MIRIS Human Milk Analyzer). Main findings Ghrelin increased from 3 to 6 months (p p R ≥ 0.321, p ≤ 0.001) and gain in FM% from 1 to 6 months(R ≥ 0.204, p = 0.001). In BF infants, also ghrelin and ghrelin/PYY ratio correlated with this gain in FM%. Exclusively BF infants had lower ghrelin and higher PYY compared to formula fed infants at 3 months (p ≤ 0.039). ARH did not correlate with macronutrients. Conclusions Increasing ghrelin and decreasing PYY, thus increasing ghrelin/PYY ratio, suggests an increasing orexigenic drive until 6 months. ARH were different between BF and FF infants at 3 months, but did not correlate with human milk macronutrients. Ghrelin and leptin, but not PYY, correlated with more FM development during the first 6 months, suggesting that they might be involved in adiposity programming. |
| Databáze: | OpenAIRE |
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