Efficacy and safety of Yunxiangjing derived from Chinese herbal medicine administered as an enema in the management of acute radiation-induced proctitis in patients with pelvic malignancy
| Autor: | Zhen Guo, Hui Wen, Yin-chun Huang, Qing Bu, Yin Liu, Wei Jiang, Guisheng Yi, Yuaying Tang, Kai-hua Feng, Xingneng Mo |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
medicine.medical_specialty medicine.medical_treatment Enema 010502 geochemistry & geophysics 01 natural sciences 03 medical and health sciences 0302 clinical medicine Quality of life Internal medicine Humans Medicine Proctitis Pelvic Neoplasms 0105 earth and related environmental sciences Medicine(all) Radiotherapy business.industry Cancer General Medicine Middle Aged medicine.disease Surgery Clinical trial Radiation therapy 030220 oncology & carcinogenesis Toxicity Female business Drugs Chinese Herbal |
| Zdroj: | Journal of Traditional Chinese Medicine. 36(1):45-50 |
| ISSN: | 0254-6272 |
| DOI: | 10.1016/s0254-6272(16)30007-3 |
| Popis: | To assess the efficacy and safety of Yunxiangjing (YXJ), derived from Chinese herbal medicine, in the management of acute radiation-induced proctitis (ARIP) in patients with pelvic malignancy.Forty-eight patients with grade 2 ARIP were administered YXJ as an enema (1 : 30 dilution) for 2 weeks and followed up for 2 years. All were assessed for response and ARIP grade. Quality of life (QOL) was assessed with the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30.Of the 48 patients, six (12.5%) achieved complete remission of ARIP and 28 (58.3%) showed a decrease from grade 2 to grade 1 ARIP. No patient experienced a grade ≥3 toxicity. At the end of radiotherapy, patients showed significant improvements in QOL (P0.05). Two years after treatment, 46 patients showed no late toxicity, with only two experiencing grade 1 late toxicity.YXJ can be used as an enema to manage acute radiation-induced proctitis in cancer patients undergoing radiotherapy. These findings suggest that YXJ enema may be an alternative treatment of ARIP. |
| Databáze: | OpenAIRE |
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