Age-corrected hearing loss after chemoradiation in cervical cancer patients
Autor: | Simone Marnitz, L. Schermeyer, Volker Budach, Christhardt Köhler, Heidi Olze, Peter Martus, S Dommerich |
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Rok vydání: | 2018 |
Předmět: |
Adult
medicine.medical_specialty Hearing loss medicine.medical_treatment Uterine Cervical Neoplasms 03 medical and health sciences 0302 clinical medicine Quality of life Risk Factors Internal medicine otorhinolaryngologic diseases Humans Medicine Radiology Nuclear Medicine and imaging Hearing Loss 030223 otorhinolaryngology Cervical cancer Cisplatin Chemotherapy Absolute threshold of hearing Dose-Response Relationship Drug medicine.diagnostic_test business.industry Age Factors Auditory Threshold Chemoradiotherapy Middle Aged medicine.disease Combined Modality Therapy Radiation therapy Acoustic Impedance Tests Oncology 030220 oncology & carcinogenesis Speech Discrimination Tests Audiometry Pure-Tone Female medicine.symptom Audiometry business medicine.drug |
Zdroj: | Strahlentherapie und Onkologie. 194:1039-1048 |
ISSN: | 1439-099X 0179-7158 |
Popis: | This study aimed to evaluate subjective and objective hearing loss in cervical cancer patients after chemoradiation with cisplatin (mono). A total of 51 cervical cancer patients with indication for chemoradiation were included. Pure tone and impedance audiometry were performed before and after chemoradiation. Hearing loss was scaled according to ASHA criteria. Subjective hearing was assessed with the Oldenburger Sentence Test. To consider age-dependent changes, hearing loss was corrected for age and the time interval between measurements. Median age at diagnosis was 46 years, 46% were active/former smokers (n = 24), 28 (54%) patients were never-smokers. Median total weekly cisplatin dose was 70 ± 14.2 mg. Cumulative doses of cisplatin during chemoradiation ranged between 115.2 and 400 mg cisplatin (mean 336.1 mg, median 342 ± 52.7 mg). The median interval between last chemotherapy and second audiometry was 320 ± 538 days (35–2262 days). Changes in hearing threshold ≥20 dB were experienced by 32/52 patients (62%) following chemoradiation, 55% of them for frequencies ≥6000 Hz. No statistically significant hearing loss remained after chemoradiation upon correction for age and time interval. Patients >40 years had a higher risk of hearing loss than younger patients. Objective data on hearing function did not correlate with subjective hearing loss and did not impair daily activity in any patient. Chemoradiation with cumulative cisplatin doses up to 400 mg did not lead to significant impairment of objective or subjective hearing. For cervical cancer patients undergoing chemoradiation, standard audiometry is not indicated. |
Databáze: | OpenAIRE |
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