The value of the signal intensity of peritumoral tissue on Gd-EOB-DTPA dynamic enhanced MRI in assessment of microvascular invasion and pathological grade of hepatocellular carcinoma
| Autor: | Yong-Sheng Xu, Yu Dou, Shun-Lin Guo, Jun-Qiang Lei, Junfeng Li, Jin-Kui Li, Li‑Li Wang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Gadolinium DTPA
Male Hepatocellular carcinoma Contrast Media 0302 clinical medicine 030212 general & internal medicine Liver Neoplasms Area under the curve General Medicine Middle Aged Prognosis Magnetic Resonance Imaging Liver Microvascular Invasion 030220 oncology & carcinogenesis Preoperative Period Pathological Grade Female Research Article Adult medicine.medical_specialty Carcinoma Hepatocellular Observational Study Disease-Free Survival 03 medical and health sciences Predictive Value of Tests Parenchyma medicine Hepatectomy Humans Neoplasm Invasiveness Survival rate Pathological Aged Retrospective Studies Receiver operating characteristic business.industry medicine.disease Gd-EOB-DTPA Log-rank test ROC Curve Microvessels Histopathology Neoplasm Grading Neoplasm Recurrence Local Nuclear medicine business Follow-Up Studies |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 0025-7974 |
| DOI: | 10.1097/md.0000000000025804 |
| Popis: | The aim of the study was to assess the potential role of preoperative gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) dynamic enhanced MR imaging for diagnosing microvascular invasion (MVI) and pathological grade of hepatocellular carcinoma (HCC). A total of 113 consecutive HCC patients confirmed by histopathology underwent preoperative Gd-EOB-DTPA dynamic enhanced MRI were included. Signal intensity (SI) of peritumoral, normal liver tissue and tumor parenchyma during arterial phase and hepatobiliary phase (HBP) were analyzed. The receiver operating characteristic (ROC) curves were performed to assess the potential diagnostic capability for MVI and pathological grade of HCC. Kaplan–Meier method was performed to estimate the recurrence-free survival rate and compared using the log rank test. SI ratio of peritumoral tissue to normal liver in arterial phase (SIAp/Al) was independently associated with MVI [odds ratio (OR) = 3.115, 95% confidence interval (CI): 1.867–5.198] and pathological grades (OR = 1.437, 95% CI: 1.042–1.981). The area under the curve (AUC) of SIAp/Al was equivalent to the SI of tumor parenchyma on arterial phase (SIAt) in distinguishing low and high pathological grades. However, the AUC of SIAp/Al (0.851) was larger than peritumoral hypointensity on HBP (0.668) for distinguishing MVI. The recurrence-free survival rate of HCC patients with SIAp/Al |
| Databáze: | OpenAIRE |
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