Inactive systemic lupus erythematosus id associated with a normal stimulated Th(1)/Th(2) cytokine secretory pattern
| Autor: | Rosalia Rosenberg, Joshua Weissgarten, Anat Mor, Mirit Amit, Arjeh J. Wysenbeek, Micha J. Rapoport, Yoram Ramot |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
Male Time Factors medicine.medical_treatment Immunology Biochemistry Peripheral blood mononuclear cell Interferon-gamma Th2 Cells immune system diseases medicine Immunology and Allergy Humans Lupus Erythematosus Systemic Secretion skin and connective tissue diseases Molecular Biology Lupus erythematosus business.industry Case-control study Hematology Middle Aged Th1 Cells medicine.disease Proliferative response Interleukin-10 Kinetics Cytokine Case-Control Studies Leukocytes Mononuclear Cytokines Interleukin-2 Female Interleukin-4 business Inactive disease Anti-SSA/Ro autoantibodies |
| Zdroj: | Cytokine. 12(9) |
| ISSN: | 1043-4666 |
| Popis: | Objectives—To determine the Th1/Th2balance in systemic lupus erythematosus (SLE) patients with inactive disease. Methods—A comprehensive analysis of peak secretion, overall cytokine production and secretory pattern of Th1and Th2cytokines from stimulated PBMC of 10 SLE patients with inactive disease and 10 age- and sex-matched controls. Results—No significant differences were found in the peak and total secretion of all cytokines, as well as in the Th1and Th2secretory patterns and proliferative response between the two groups. Conclusion—Th1and Th2balance in inactive SLE is normal. |
| Databáze: | OpenAIRE |
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