Demands and challenges for patients with sickle-cell disease requiring hematopoietic stem cell transplantation in Saudi Arabia
| Autor: | Muneer H. Al Bagshi, Sameera Al Afghani, Ahmed M. Al-Suliman, Abdulrahman Alsultan, Wasil Jastaniah, Zaki Nasserullah, Mohammed K. Alabdulaali |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Adolescent medicine.medical_treatment education Saudi Arabia Anemia Sickle Cell Hematopoietic stem cell transplantation Disease 030204 cardiovascular system & hematology Young Adult 03 medical and health sciences 0302 clinical medicine Cost of Illness hemic and lymphatic diseases parasitic diseases medicine Humans Severe pain Child Intensive care medicine Stroke Transplantation business.industry Patient Selection Hematopoietic Stem Cell Transplantation Middle Aged medicine.disease Cross-Sectional Studies surgical procedures operative Curative treatment Child Preschool 030220 oncology & carcinogenesis Allogeneic hsct Pediatrics Perinatology and Child Health Cohort Female business Needs Assessment geographic locations |
| Zdroj: | Pediatric Transplantation. 20:831-835 |
| ISSN: | 1397-3142 |
| Popis: | Allogeneic HSCT is the only curative treatment for SCD. In this study, we estimated the number of Saudi patients with SCD who are candidates for HSCT. We used the presence of overt stroke, recurrent ACS, and frequent severe pain crisis as indications for HSCT. We calculated the frequencies of these complications among a Saudi SCD cohort of 376 patients with SCD, 250 from SW and 126 from Eastern (E) provinces. We found that 59 (23.6%) of SW patients were transplant candidates compared to 22 (17.4%) from E province. It is estimated that about 61 000 patients with SCD live in Saudi Arabia. Thus, the projected number of Saudi patients with SCD who are candidates for HSCT is 10 536 patients. Of those, 2148 are children. The burden of SCD on HSCT centers in Saudi Arabia is substantial and is difficult currently to meet the demand. We recommend recruiting/training more transplant physicians and nurses, expand current capacity of centers if feasible, and open new transplant centers to make HSCT a practical therapeutic option for patients with severe SCD in Saudi Arabia. |
| Databáze: | OpenAIRE |
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