Systematic review of melatonin treatment in children with neurodevelopmental disabilities and sleep impairment
| Autor: | Richard Appleton, Louise Phillips |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Sleep Wake Disorders
Pediatrics medicine.medical_specialty Developmental Disabilities Placebo Antioxidants law.invention Melatonin Developmental Neuroscience Randomized controlled trial law Humans Medicine Circadian rhythm Wakefulness Child Psychiatry Sleep disorder business.industry Brain medicine.disease Sleep in non-human animals Pediatrics Perinatology and Child Health Neurology (clinical) Sleep onset business medicine.drug |
| Zdroj: | Developmental Medicine & Child Neurology. 46 |
| ISSN: | 1469-8749 0012-1622 |
| Popis: | Sleep disturbances in children with neurodevelopmental disabilities are common and frequently difficult to treat with conventional pharmacological and behavioural methods. Melatonin is a pineal hormone known to be important in the regulation of the circadian rhythm, including the sleep-wake cycle. This systematic review of available evidence from randomized clinical trials assesses whether melatonin plays a beneficial role in these children and, in particular, its effect on total sleep time, time to sleep onset (sleep latency), and number of awakenings. We also looked at a parental view of the effect. Randomized clinical trials were identified where oral melatonin was compared with a placebo in children with any type of neurodevelopmental disability and associated sleep disturbance. Only three studies, reporting a total of 35 children, fulfilled the criteria for inclusion. The two studies that reported time to sleep onset showed a significant decrease (p |
| Databáze: | OpenAIRE |
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