Antibacterial and immunomodulatory activities of bovine lactoferrin against Escherichia coli O157:H7 infections in cattle
| Autor: | Eric Cox, Joanna Rybarczyk, Evelien Kieckens, Daisy Vanrompay |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Lipopolysaccharide medicine.drug_class 030106 microbiology Antibiotics Escherichia coli O157 medicine.disease_cause General Biochemistry Genetics and Molecular Biology Microbiology Biomaterials Feces 03 medical and health sciences chemistry.chemical_compound fluids and secretions Immunity medicine Animals Humans Escherichia coli Escherichia coli Infections Gastrointestinal tract biology business.industry Metals and Alloys Shiga toxin biology.organism_classification Anti-Bacterial Agents Lactoferrin chemistry biology.protein Cattle Bloody diarrhea General Agricultural and Biological Sciences business Bacteria |
| Zdroj: | BioMetals. 31:321-330 |
| ISSN: | 1572-8773 0966-0844 |
| DOI: | 10.1007/s10534-018-0082-x |
| Popis: | Enterohemorrhagic Escherichia coli (EHEC) O157:H7 is a zoonotic pathogen that causes food-borne disease in humans ranging from watery diarrhea to bloody diarrhea and severe hemorrhagic colitis, renal failure and hemolytic uremic syndrome. Cattle, the most important source of E. coli O157:H7 transmission to humans, harbor the bacteria in their gastrointestinal tract without showing clinical symptoms. Prevention of E. coli O157:H7 infections in ruminants could diminish the public health risk. However, there is no specific treatment available nor a vaccine or a therapeutic agent which completely prevents E. coli O157:H7 infections in cattle. This paper provides an overview of latest research data on eradicating enterohemorrhagic E. coli O157:H7 in ruminants by use of bovine lactoferrin administration. The article provides insights into the anti-microbial and immunomodulatory activities of bovine lactoferrin against E. coli O157:H7 infections in cattle. |
| Databáze: | OpenAIRE |
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