Collagenase-2 (matrix metalloproteinase-8) plays a protective role in tongue cancer

Autor: Emma Pirilä, Timo Sorsa, Tuula Salo, M Lahtinen, Esa Läärä, H. Maklin, Jarkko T. Korpi, Saara Kantola, V Kervinen, Gareth J. Thomas, M. Ylipalosaari, Pirjo Åström, Anu Väänänen, Carlos López-Otín, Ari Ristimäki
Jazyk: angličtina
Rok vydání: 2008
Předmět:
squamous cell carcinoma
Male
Cancer Research
Pathology
Immunoenzyme Techniques
Mice
0302 clinical medicine
tongue
Tumor Cells
Cultured
Mouth neoplasm
Aged
80 and over
Mice
Knockout
0303 health sciences
Reverse Transcriptase Polymerase Chain Reaction
matrix metalloproteinases
Middle Aged
4-Nitroquinoline-1-oxide
3. Good health
oestrogen receptor
Tongue Neoplasms
medicine.anatomical_structure
Matrix Metalloproteinase 8
Oncology
Epidermoid carcinoma
030220 oncology & carcinogenesis
Carcinoma
Squamous Cell
Interstitial collagenase
Female
Mouth Neoplasms
MMP-8
Adult
medicine.medical_specialty
Blotting
Western
Biology
03 medical and health sciences
Tongue
Tongue Carcinoma
medicine
Carcinoma
Biomarkers
Tumor
Animals
Estrogen Receptor beta
Humans
RNA
Messenger
Tongue Neoplasm
030304 developmental biology
Aged
Estrogen Receptor alpha
Cancer
medicine.disease
Carcinogens
Translational Therapeutics
oestrogen
Zdroj: British Journal of Cancer
ISSN: 1532-1827
0007-0920
Popis: Squamous cell carcinoma (SCC) of the tongue is the most common cancer in the oral cavity and has a high mortality rate. A total of 90 mobile tongue SCC samples were analysed for Bryne's malignancy scores, microvascular density, and thickness of the SCC sections. In addition, the staining pattern of cyclooxygenase-2, alphavbeta6 integrin, the laminin-5 gamma2-chain, and matrix metalloproteinases (MMPs) -2, -7, -8, -9, -20, and -28 were analysed. The expression of MMP-8 (collagenase-2) was positively associated with improved survival of the patients and the tendency was particularly prominent in females. No sufficient evidence for a correlation with the clinical outcome was found for any other immunohistological marker. To test the protective role of MMP-8 in tongue carcinogenesis, MMP-8 knockout mice were used. MMP-8 deficient female mice developed tongue SCCs at a significantly higher incidence than wild-type mice exposed to carcinogen 4-Nitroquinoline-N-oxide. Consistently, oestrogen-induced MMP-8 expression in cultured HSC-3 tongue carcinoma cells, and MMP-8 cleaved oestrogen receptor (ER) alpha and beta. According to these data, we propose that, contrary to the role of most proteases produced by human carcinomas, MMP-8 has a protective, probably oestrogen-related role in the growth of mobile tongue SCCs.
Databáze: OpenAIRE
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