Lipid peroxidation in face of DNA damage, DNA repair and other cellular processes
| Autor: | Anna Fabisiewicz, Agnieszka Tudek, Konrad Kosicki, Elżbieta Speina, Daria Zdżalik-Bielecka, Barbara Tudek |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Aging DNA Repair Carcinogenesis DNA damage DNA repair AlkB Biochemistry DNA Glycosylases DNA Adducts 03 medical and health sciences chemistry.chemical_compound Physiology (medical) Animals Humans Homologous Recombination biology Base excision repair Molecular biology 030104 developmental biology Adductomics chemistry Mutagenesis biology.protein Lipid Peroxidation Homologous recombination Oxidation-Reduction DNA DNA Damage Nucleotide excision repair |
| Zdroj: | Tudek, B, Zdżalik-Bielecka, D, Tudek, A, Kosicki, K, Fabisiewicz, A & Speina, E 2017, ' Lipid peroxidation in face of DNA damage, DNA repair and other cellular processes ', Free Radical Biology & Medicine, vol. 107, pp. 77-89 . https://doi.org/10.1016/j.freeradbiomed.2016.11.043 |
| Popis: | Exocyclic adducts to DNA bases are formed as a consequence of exposure to certain environmental carcinogens as well as inflammation and lipid peroxidation (LPO). Complex family of LPO products gives rise to a variety of DNA adducts, which can be grouped in two classes: (i) small etheno-type adducts of strong mutagenic potential, and (ii) bulky, propano-type adducts, which block replication and transcription, and are lethal lesions. Etheno-DNA adducts are removed from the DNA by base excision repair (BER), AlkB and nucleotide incision repair enzymes (NIR), while substituted propano-type lesions by nucleotide excision repair (NER) and homologous recombination (HR). Changes of the level and activity of several enzymes removing exocyclic adducts from the DNA was reported during carcinogenesis. Also several beyond repair functions of these enzymes, which participate in regulation of cell proliferation and growth, as well as RNA processing was recently described. In addition, adducts of LPO products to proteins was reported during aging and age-related diseases. The paper summarizes pathways for exocyclic adducts removal and describes how proteins involved in repair of these adducts can modify pathological states of the organism. |
| Databáze: | OpenAIRE |
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