Is the relative99mTc-DMSA clearance a useful marker of proximal tubular dysfunction?
| Autor: | Ajm Donker, Gj Ensing, Da Piers, Whj Vanluijk, Sytze Meijer |
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| Rok vydání: | 1984 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Adolescent Urology Renal Circulation Iodine Radioisotopes Kidney Tubules Proximal medicine Humans Radiology Nuclear Medicine and imaging Sulfhydryl Compounds Child Radionuclide Imaging Aged business.industry Hippurates Infant Technetium General Medicine Middle Aged Iothalamic Acid Filtration fraction Tc-99m DMSA Proximal Tubulopathy Child Preschool Technetium Tc 99m Dimercaptosuccinic Acid Female Kidney Diseases Succimer beta 2-Microglobulin business Glomerular Filtration Rate |
| Zdroj: | European Journal of Nuclear Medicine. 9:439-442 |
| ISSN: | 1619-7089 0340-6997 |
| Popis: | The clearance of 125I-sodium iothalamate, 131I-sodium hippurate, 99mTc-DMSA, and beta 2-microglobulin were determined in 20 patients with proven or suspected proximal tubular dysfunction and in 18 control patients with various renal diseases. A clear distinction in the relative 99mTc-DMSA clearance was observed between patients with proximal tubulopathy (14%-35%) and control patients (less than 14%). A similar difference between the two groups was found in the relative beta 2-microglobulin clearance. Nine patients with proximal tubulopathy showed an elevated filtration fraction versus only two control patients. The renal handling of 99mTc-DMSA seems to be an indicator of proximal tubular function. |
| Databáze: | OpenAIRE |
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