Limited utility of novel serological biomarkers in patients newly suspected of having giant cell arteritis
| Autor: | Susan M. Smith, Rodger Laurent, Anthony M. Sammel, Christopher B. Little, Elisabeth Karsten, Meilang Xue, Katherine Nguyen |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
Vascular Endothelial Growth Factor A medicine.medical_specialty Biopsy Giant Cell Arteritis Enzyme-Linked Immunosorbent Assay Sensitivity and Specificity Gastroenterology Procalcitonin Interferon-gamma chemistry.chemical_compound Rheumatology Von Willebrand factor Adrenal Cortex Hormones Fluorodeoxyglucose F18 Positron Emission Tomography Computed Tomography Internal medicine von Willebrand Factor medicine Humans skin and connective tissue diseases Aged biology medicine.diagnostic_test Interleukin-6 business.industry Middle Aged medicine.disease Interleukin-12 Vascular endothelial growth factor Serum Amyloid P-Component Giant cell arteritis C-Reactive Protein chemistry Positron emission tomography Erythrocyte sedimentation rate Cohort biology.protein business Vasculitis Biomarkers |
| Zdroj: | International Journal of Rheumatic Diseases. 24:781-788 |
| ISSN: | 1756-185X 1756-1841 |
| DOI: | 10.1111/1756-185x.14111 |
| Popis: | AIM Diagnosing and monitoring vascular activity in giant cell arteritis (GCA) is difficult due to the paucity of specific serological biomarkers. We assessed the utility of 8 novel biomarkers in an inception cohort of newly suspected GCA patients. METHOD Consecutive patients were enrolled between May 2016 and December 2017. Serum was collected within 72 hours of commencing corticosteroids and at 6 months. It was analyzed for levels of intra-cellular adhesion molecule 1, vascular endothelial growth factor (VEGF), pentraxin 3, von Willebrand factor and procalcitonin (5-plex R&D Systems multiplex assay) and interleukin (IL)6, IL12 and interferon-γ (high-sensitivity 3-plex ProcartaPlex multiplex assay). A GCA specific positron emission tomography / computed tomography (PET/CT) scan was performed at enrolment with uptake in each vascular territory graded and summed to derive a total vascular score (TVS). RESULTS For the 63 patients enrolled, 12 (19%) had a final diagnosis of biopsy-positive GCA and a further 9 had a clinical diagnosis of biopsy-negative GCA. None of the 8 biomarkers was significantly higher in GCA patients compared with those with alternative diagnoses, or demonstrated a positive correlation with the PET/CT TVS. This was in contrast to the C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) which were higher in the biopsy-positive GCA cohort (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|