Immune monitoring of immunosuppression withdrawal of liver transplant recipients
| Autor: | Rocío García de la Garza, Jorge Quiroga, Pablo Sarobe, Fernando Pardo, Bruno Sangro, Juan José Lasarte, J. Ignacio Herrero, Leyre Silva, Virginia Belsúe, Delia D'Avola, Jose Antonio Delgado, Juana Merino, Iosu Sola, Mercedes Iñarrairaegui |
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| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_treatment
Lymphocyte Immunology Immunologic Tests Liver transplantation Biology T-Lymphocytes Regulatory Immunophenotyping Immune tolerance Antigens CD Immune Tolerance medicine Humans Immunology and Allergy Monitoring Physiologic Immunosuppression Therapy Transplantation Immunosuppression Lymphocyte Subsets Liver Transplantation Substance Withdrawal Syndrome Interleukin 10 medicine.anatomical_structure Withholding Treatment Interleukin 12 Cytokines Tumor necrosis factor alpha Follow-Up Studies |
| Zdroj: | Transplant Immunology. 33:110-116 |
| ISSN: | 0966-3274 |
| DOI: | 10.1016/j.trim.2015.07.006 |
| Popis: | Several studies have shown that some liver transplant recipients may tolerate immunosuppression withdrawal. Mechanisms and biomarkers of tolerance are not well known. Methods Twenty-four LT patients with immunosuppression side-effects underwent progressive immunosuppression withdrawal. Peripheral lymphocyte populations and secretion of cytokines were analyzed at baseline and during withdrawal until tolerance (n = 15) or rejection (n = 9), as well as 3 months after tolerance achievement or rejection resolution (as follow-up). Immunological markers were compared among groups. Results The percentages of CD3 + CD4 + cells progressively decreased in both groups. CD3 + CD8 + cells gradually increased in tolerant patients. B lymphocytes gradually decreased in tolerant and initially in non-tolerant patients, reverting at rejection. Regulatory T cells progressively increased until rejection in non-tolerants, decreasing to basal levels after renewing immunosuppression; no significant changes were found in tolerant patients. The percentages and absolute counts of natural killer cells significantly increased in both groups, being more evident in tolerant patients. The secretion of several cytokines was higher in non-tolerant patients when rejection was diagnosed. Conclusions The greater increase of natural killer cells in tolerant patients suggests their potential role in the tolerance phenomenon. |
| Databáze: | OpenAIRE |
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