Effect of Intravenous Epinephrine on Uterine Artery Blood Flow Velocity in the Pregnant Guinea Pig
| Autor: | Joseph G. Martin, David H. Chestnut, Jin Ping Wang, Carl P. Weiner, James E. Herrig |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
medicine.medical_specialty
Mean arterial pressure Epinephrine Lidocaine medicine.drug_class Guinea Pigs Injections Epidural Hemodynamics Blood Pressure Guinea pig Heart Rate Pregnancy Internal medicine medicine.artery Heart rate medicine Animals Uterine artery business.industry Local anesthetic Uterus Blood flow Anesthesiology and Pain Medicine Blood pressure Endocrinology Anesthesia Injections Intravenous Catecholamine Pregnancy Animal Female business Blood Flow Velocity medicine.drug |
| Zdroj: | Anesthesiology. 65:633-636 |
| ISSN: | 0003-3022 |
| DOI: | 10.1097/00000542-198612000-00011 |
| Popis: | The purpose of the present study was to determine the effect of intravenously administered epinephrine on the maternal cardiovascular response and uterine artery blood flow velocity (UBFV) in the pregnant guinea pig. Epinephrine (0.2, 0.5, and 1.0 micrograms/kg) and lidocaine (0.4 mg/kg, with and without 0.2 micrograms/kg of epinephrine) were administered intravenously to seven chronically instrumented pregnant guinea pigs near term. Lidocaine without epinephrine did not significantly alter maternal heart rate (MHR), maternal mean arterial pressure (MMAP), or UBFV. Epinephrine, with and without lidocaine, resulted in a transient decrease in MHR. Further, epinephrine, with and without lidocaine, resulted in significant elevations in MMAP and significant, dose-related reductions in UBFV. Mean (+/- SEM) UBFV was 72 +/- 4%, 56 +/- 4%, and 40 +/- 5% of baseline at 30 s after administration of epinephrine, 0.2, 0.5, and 1.0 micrograms/kg, respectively. It is concluded that these small intravenous boluses of epinephrine result in significant, although transient, reductions in UBFV in the pregnant guinea pig. |
| Databáze: | OpenAIRE |
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