In Vitro Human Joint Models Combining Advanced 3D Cell Culture and Cutting-Edge 3D Bioprinting Technologies

Autor: Christian Jorgensen, Matthieu Simon
Přispěvatelé: Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Retiveau, Nolwenn
Jazyk: angličtina
Rok vydání: 2021
Předmět:
0301 basic medicine
[SDV.BIO]Life Sciences [q-bio]/Biotechnology
Stromal cell
Computer science
MESH: Printing
Three-Dimensional
Cell Culture Techniques
[SDV.BC]Life Sciences [q-bio]/Cellular Biology
02 engineering and technology
Fluid circulation
Review
MESH: Organoids
External pressure
law.invention
03 medical and health sciences
3D cell culture
MESH: Osteoarthritis
law
Osteoarthritis
Humans
MESH: Bioprinting
lcsh:QH301-705.5
[SDV.BC] Life Sciences [q-bio]/Cellular Biology
MESH: Cell Culture Techniques
3D bioprinting
MESH: Humans
Bioprinting
Rheumatic disease
General Medicine
021001 nanoscience & nanotechnology
[SDV.BIO] Life Sciences [q-bio]/Biotechnology
Organoids
microspheres
030104 developmental biology
musculoskeletal progenitor/stromal cells
lcsh:Biology (General)
Printing
Three-Dimensional
Joint (building)
0210 nano-technology
Oxygen level
Neuroscience
Zdroj: Cells
Cells, MDPI, 2021, 10 (3), pp.596. ⟨10.3390/cells10030596⟩
Cells, Vol 10, Iss 596, p 596 (2021)
ISSN: 2073-4409
DOI: 10.3390/cells10030596⟩
Popis: International audience; Joint-on-a-chip is a new technology able to replicate the joint functions into microscale systems close to pathophysiological conditions. Recent advances in 3D printing techniques allow the precise control of the architecture of the cellular compartments (including chondrocytes, stromal cells, osteocytes and synoviocytes). These tools integrate fluid circulation, the delivery of growth factors, physical stimulation including oxygen level, external pressure, and mobility. All of these structures must be able to mimic the specific functions of the diarthrodial joint: mobility, biomechanical aspects and cellular interactions. All the elements must be grouped together in space and reorganized in a manner close to the joint organ. This will allow the study of rheumatic disease physiopathology, the development of biomarkers and the screening of new drugs.
Databáze: OpenAIRE
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