RETRACTED: Genetic Susceptibility Model of Parkinson’s Disease Resulting from Exposure of DJ-1 Deficient Mice to MPTP: Evaluation of Neuroprotection by Ubisol-Q10
| Autor: | Siyaram Pandey, Krithika Muthukumaran, Harshil Jasra, Jagdeep K. Sandhu, Jessica Smith, Daniel Lopatin, Jerome S. Cohen, Marianna Sikorska |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Genetically modified mouse Parkinson's disease Tyrosine 3-Monooxygenase Ubiquinone Protein Deglycase DJ-1 Motor Activity Pharmacology Neuroprotection Mice Cellular and Molecular Neuroscience chemistry.chemical_compound Genetic predisposition Animals Medicine Genetic Predisposition to Disease Pars Compacta Mice Knockout Neurons Oncogene Proteins business.industry MPTP Neurodegeneration PARK7 Neurotoxicity MPTP Poisoning Peroxiredoxins medicine.disease Mice Inbred C57BL Disease Models Animal Neuroprotective Agents chemistry Anesthesia Neurology (clinical) business |
| Zdroj: | Journal of Parkinson's Disease. 4:523-530 |
| ISSN: | 1877-718X 1877-7171 |
| Popis: | Introduction: Parkinson’s disease arises from a combination of environmental and genetic risk factors. At present neither the curative nor preventative therapies are available; hence, there is an urgent need to develop reliable animal models to facilitate their development. Water soluble nanomiceller formulation of CoQ10 (Ubisol-Q10) has shown neuroprotection against neurotoxin on human neuronal cells. We have combined the genetic deficiency of DJ-1/PARK7 mice with MPTP exposure and develop a genetic susceptibility model of PD and evaluated the neuroprotective efficacy of (Ubisol-Q10). Methods: Transgenic mice with DJ-1 deficiency (DJ-1/PARK7) were given either water or Ubisol-Q10 prophylactically at a dose of 6 mg/kg/day added directly to a drinking water for one month followed challenged with MPTP injections while keeping the same drinking water regiments. Four weeks after the last injection we evaluated neuroprotective efficacy of Ubisol-Q10 in DJ-1/MPTP model of PD using histochemical and behavioral readouts. Results: We confirmed genetic susceptibility to MPTP and showed that prophylactic oral treatment with Ubisol-Q10 significantly offset the neurotoxicity and ameliorated motor dysfunction, otherwise correlated with the MPTP injury. Conclusion: Ubisol-Q10 protects against MPTP-induced neurodegeneration and motor dysfunction in DJ-1 deficient mice. Ubisol-Q10 might be a treatment prospect for people genetically predisposed to PD as well as with sporadic PD. |
| Databáze: | OpenAIRE |
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