Defining the blood pressure QTL on Chromosome 7 in Dahl rats by a 177-kb congenic segment containing Cyp11b1

Autor:	Michael R. Garrett, John P. Rapp
Rok vydání:	2003
Předmět:	Male Genetics Chromosome 7 (human) Rodent biology Quantitative Trait Loci Congenic Chromosome Mapping Chromosome Blood Pressure Quantitative trait locus Rats Blood pressure biology.animal Animals Steroid 11-beta-Hydroxylase Steroid 11-beta-hydroxylase Gene
Zdroj:	Mammalian Genome. 14:268-273
ISSN:	1432-1777 0938-8990
DOI:	10.1007/s00335-002-2245-9
Popis:	Previously we reported that there is a blood pressure quantitative trait locus (QTL) on rat Chromosome (Chr) 7 seen when comparing Dahl salt-sensitive (S) rats and Dahl salt-resistant (R) rats. Evidence was also presented that this QTL was due to genetic variants in the adrenal steroidogenic enzyme 11beta-hydroxylase ( Cyp11b1). A series of congenic strains supported this contention. In the present work we have constructed a final congenic substrain that retains a blood pressure effect and that has an introgressed congenic segment which includes Cyp11b1 and is < 177 kb in size. None of the other genes in the congenic region (eight known genes) have known biological functions for influencing blood pressure. We believe that we have reached the limit of resolution for congenic analysis of a QTL in a rodent animal model, and we conclude that Cyp11b1 causes the observed QTL on rat Chr 7 in Dahl rats.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf05d5b0d1dd044d6037fb9b4e9c5029 https://doi.org/10.1007/s00335-002-2245-9 Zobrazit plný text záznamu Plný text ve formátu PDF