Intake of n-3 polyunsaturated fatty acids in childhood, FADS genotype, and incident asthma
| Autor: | Mohammad Talaei, Philip C. Calder, Louise R Jones, Emmanouela Sdona, Pauline M Emmett, Raquel Granell, Seif O. Shaheen, Anna Bergström, Erik Melén |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Pulmonary and Respiratory Medicine
eicosapentaenoic acid Physiology Lower risk 03 medical and health sciences 0302 clinical medicine Medicine 030212 general & internal medicine childhood Asthma 2. Zero hunger chemistry.chemical_classification biology business.industry Odds ratio ALSPAC docosahexaenoic acid asthma medicine.disease Eicosapentaenoic acid Confidence interval 3. Good health Fatty acid desaturase 030228 respiratory system chemistry Docosahexaenoic acid biology.protein fatty acid desaturases lipids (amino acids peptides and proteins) business Polyunsaturated fatty acid |
| Zdroj: | Talaei, M, Sdona, E, Calder, P, Jones, L R, Emmett, P M, Granell, R, Bergstrom, A, Melén, E & Shaheen, S O 2021, ' Intake of n-3 polyunsaturated fatty acids in childhood, FADS genotype, and incident asthma ', ERJ Open Research, vol. 58, no. 3, 2003633 . https://doi.org/10.1183/13993003.03633-2020 |
| Popis: | Longitudinal evidence on the relation between dietary intake of n-3 (ω-3) very-long-chain polyunsaturated fatty acids, i.e. eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), in mid-childhood and asthma risk is scarce. We aimed to investigate whether a higher intake of EPA and DHA from fish in childhood is associated with a lower risk of incident asthma.In the Avon Longitudinal Study of Parents and Children, dietary intakes of EPA and DHA from fish were estimated by food frequency questionnaire at 7 years of age. We used logistic regression, controlling for confounders, to analyse associations between intake of EPA and DHA (quartiles) and incidence of doctor-diagnosed asthma at age 11 or 14 years, and explored potential effect modification by a fatty acid desaturase (FADS) polymorphism (rs1535). Replication was sought in the Swedish BAMSE birth cohort.There was no evidence of association between intake of EPA plus DHA from fish and incident asthma overall (n=4543). However, when stratified by FADS genotype, the odds ratio comparing the top versus bottom quartile among the 2025 minor G allele carriers was 0.49 (95% CI 0.31–0.79; ptrend=0.006), but no inverse association was observed in the homozygous major A allele group (OR 1.43, 95% CI 0.83–2.46; ptrend=0.19) (pinteraction=0.006). This gene–nutrient interaction on incident asthma was replicated in BAMSE.In children with a common FADS variant, higher intake of EPA and DHA from fish in childhood was strongly associated with a lower risk of incident asthma up to mid-adolescence. |
| Databáze: | OpenAIRE |
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