EANM guideline for harmonisation on molar activity or specific activity of radiopharmaceuticals
| Autor: | Philip H. Elsinga, Yann Seimbille, Antony D. Gee, Verena Pichler, Johnny Vercouillie, Salvatore Bongarzone, Gert Luurtsema |
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| Přispěvatelé: | Radiology & Nuclear Medicine, Molecular Neuroscience and Ageing Research (MOLAR), Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE), Guided Treatment in Optimal Selected Cancer Patients (GUTS) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Computer science TRACER Specific activity (A(s)) AUTOMATED SYNTHESIS R895-920 RM1-950 Analytical Chemistry Guideline Article Medical physics. Medical radiology. Nuclear medicine BINDING Tracers medicine Molar activity (Am) Pharmacology (medical) Radiology Nuclear Medicine and imaging Medical physics IN-VIVO Pharmacology Radiochemistry BLOOD-BRAIN-BARRIER Molar activity (A(m)) Guideline Mass QUANTITATIVE-ANALYSIS C-11 RACLOPRIDE Highly sensitive Radioactivity P-GLYCOPROTEIN FUNCTION LIVING HUMAN-BRAIN PET Specific activity (As) Imaging quality Pet scanner Specific activity Standardisation Carrier Therapeutics. Pharmacology |
| Zdroj: | EJNMMI Radiopharmacy and Chemistry, Vol 6, Iss 1, Pp 1-16 (2021) EJNMMI Radiopharmacy and Chemistry, 6(1):34. Springer Science+Business Media EJNMMI Radiopharmacy and Chemistry, 6(1):34, 1-16. Springer EJNMMI Radiopharmacy and Chemistry |
| ISSN: | 2365-421X |
| Popis: | This guideline on molar activity (Am) and specific activity (As) focusses on small molecules, peptides and macromolecules radiolabelled for diagnostic and therapeutic applications. In this guideline we describe the definition of Am and As, and how these measurements must be standardised and harmonised. Selected examples highlighting the importance of Am and As in imaging studies of saturable binding sites will be given, and the necessity of using appropriate materials and equipment will be discussed. Furthermore, common Am pitfalls and remedies are described. Finally, some aspects of Am in relation the emergence of a new generation of highly sensitive PET scanners will be discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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