Time-related alterations of superoxide radical levels in diverse organs of bile duct-ligated rats

Autor:	Ioannis Papapostolou, Dimitris Konstantinou, Konstantinos Faropoulos, Christos D. Georgiou, Elisabeth Chroni, Adamantios Mavrakis, Nikolaos Karageorgos, Konstantinos Grintzalis, Stelios F Assimakopoulos
Rok vydání:	2009
Předmět:	Male medicine.medical_specialty Pathology Kidney medicine.disease_cause Biochemistry Superoxides In vivo Internal medicine medicine Animals Intestinal Mucosa Rats Wistar Ligation Fluorescent Dyes Common Bile Duct chemistry.chemical_classification Reactive oxygen species Chemistry Bile duct Brain General Medicine Dicarbethoxydihydrocollidine Rats Disease Models Animal Jaundice Obstructive Kinetics Oxidative Stress Spectrometry Fluorescence medicine.anatomical_structure Endocrinology Liver Superoxide radical Obstructive jaundice Gradual increase Oxidative stress
Zdroj:	Free Radical Research. 43:803-808
ISSN:	1029-2470 1071-5762
DOI:	10.1080/10715760903062903
Popis:	The time-related alterations of superoxide radical measured in vivo by employing an ultrasensitive fluorescent assay in the liver, intestine, kidney and brain of rats with experimentally induced obstructive jaundice was investigated. Eighteen rats were randomly divided into Group A, rats subjected to sham operation, and Group B, rats subjected to bile duct ligation (BDL). Three rats from each group were subsequently killed at different time points post-operatively (1, 5 and 10 days). As compared to sham-operated, BDL rats showed a gradual increase with time of superoxide radical in the intestine, liver, kidney and brain: for animals sacrificed on the 1(st), 5(th) and 10(th) day the increase was 45%, 50% and 96% in the liver, 76%, 81% and 118% in the intestine, 64%, 71% and 110% in the kidney and 76%, 95% and 142% in the brain, respectively. This study provides direct evidence of an early appearance of oxidative stress in diverse organs, implying a uniform systemic response to biliary obstruction and emphasizing the need of early bile flow restoration.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cefe82c2d915061ba7fa044e1aa71f34 https://doi.org/10.1080/10715760903062903 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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