A PET study in healthy subjects of brain exposure of (11)C-labelled osimertinib – A drug intended for treatment of brain metastases in non-small cell lung cancer
| Autor: | Christer Halldin, Andrew P. Brown, Peter Johnström, Mohammad Mahdi Moein, Karthick Vishwanathan, Magnus Schou, Lars Farde, Andrea Varrone, Aurelija Jucaite, Zsolt Cselényi, Ana Vazquez-Romero, Katarina Varnäs |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Drug
Adult Male medicine.drug_class media_common.quotation_subject Antineoplastic Agents Blood–brain barrier Tyrosine-kinase inhibitor 03 medical and health sciences 0302 clinical medicine MicroDose Carcinoma Non-Small-Cell Lung medicine Humans Osimertinib Tissue Distribution Epidermal growth factor receptor Carbon Radioisotopes Lung cancer media_common Acrylamides Aniline Compounds biology business.industry Brain Neoplasms Brain Original Articles Middle Aged medicine.disease Magnetic Resonance Imaging Healthy Volunteers medicine.anatomical_structure Neurology Blood-Brain Barrier 030220 oncology & carcinogenesis Positron-Emission Tomography Injections Intravenous Cancer research biology.protein Neurology (clinical) Cardiology and Cardiovascular Medicine business 030217 neurology & neurosurgery Brain metastasis |
| Zdroj: | J Cereb Blood Flow Metab |
| Popis: | Osimertinib is a tyrosine kinase inhibitor (TKI) of the mutated epidermal growth factor receptor (EGFRm) with observed efficacy in patients with brain metastases. Brain exposure and drug distribution in tumor regions are important criteria for evaluation and confirmation of CNS efficacy. The aim of this PET study was therefore to determine brain distribution and exposure of 11C-labelled osimertinib administered intravenously in subjects with an intact blood–brain barrier. Eight male healthy subjects (age 52 ± 8 years) underwent one PET measurement with 11C-osimertinib. The pharmacokinetic parameters Cmax (brain) (standardized uptake value), Tmax (brain) and AUC0–90 min brain/blood ratio were calculated. The outcome measure for 11C-osimertinib brain exposure was the total distribution volume ( VT). 11C-osimertinib distributed rapidly to the brain, with higher uptake in grey than in white matter. Mean Cmax, Tmax and AUC0–90 min brain/blood ratio were 1.5 (range 1–1.8), 13 min (range 5–30 min), and 3.8 (range 3.3–4.1). Whole brain and white matter VT were 14 mL×cm−3 (range 11–18) and 7 mL×cm−3 (range 5–12). This study in healthy volunteers shows that 11C-osimertinib penetrates the intact blood–brain barrier. The approach used further illustrates the role of molecular imaging in facilitating the development of novel drugs for the treatment of malignancies affecting the brain. |
| Databáze: | OpenAIRE |
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