Strength of prefrontal activation predicts intensity of suggestion-induced pain
| Autor: | Riitta Hari, Jussi Numminen, Jaana Hiltunen, Tuukka T. Raij, Sakari Närvänen |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Pain Prefrontal Cortex Neuropsychological Tests Gyrus Cinguli Brain mapping Functional Laterality Young Adult 03 medical and health sciences 0302 clinical medicine Cortex (anatomy) medicine Humans Radiology Nuclear Medicine and imaging Suggestion Prefrontal cortex Research Articles Anterior cingulate cortex Pain Measurement 030304 developmental biology Cerebral Cortex Brain Mapping 0303 health sciences Radiological and Ultrasound Technology medicine.diagnostic_test Somatosensory Cortex Placebo Effect Executive functions Illusions Magnetic Resonance Imaging Dorsolateral prefrontal cortex medicine.anatomical_structure Neurology Imagination Female Neurology (clinical) Nerve Net Anatomy Functional magnetic resonance imaging Psychology Insula Neuroscience Hypnosis 030217 neurology & neurosurgery |
| Zdroj: | Hum Brain Mapp |
| ISSN: | 1097-0193 1065-9471 |
| DOI: | 10.1002/hbm.20716 |
| Popis: | Suggestion, a powerful factor in everyday social interaction, is most effective during hypnosis. Subjective evaluations and brain‐imaging findings converge to propose that hypnotic suggestion strongly modulates sensory processing. To reveal the brain regions that mediate such a modulation, we analyzed data from a functional‐magnetic‐resonance‐imaging study on hypnotic‐suggestion‐induced pain on 14 suggestible subjects. Activation strengths in the right dorsolateral prefrontal cortex (DLPFC) during initiation of suggestion for pain correlated positively with the subjective intensity of the subsequent suggestion‐induced pain, as well as with the strengths of the maximum pain‐related activation in the in the secondary somatosensory (SII) cortex. Furthermore, activation of the insula and the anterior cingulate cortex predicted the pain‐related SII activation. The right DLPFC, as an area important for executive functions, likely contributes to functional modulation in the modality‐specific target areas of given suggestions. Hum Brain Mapp 2009. © 2009 Wiley‐Liss, Inc. |
| Databáze: | OpenAIRE |
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