Syphilis diagnosis and serological response to Benzathine Penicillin G among patients attending HIV clinics in N'Djaména, Chad
| Autor: | Franck J. D. Mennechet, Oumaïma Djarma, Chatté Adawaye, Adda Oumar Souleymane, Amandine Cournil, Abdelrazzack Adoum Fouda, Edouard Tuaillon |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Adult Male Pediatrics medicine.medical_specialty Adolescent Chad 030106 microbiology Population TPHA Human immunodeficiency virus (HIV) HIV Infections Infectious and parasitic diseases RC109-216 VDRL medicine.disease_cause Men who have sex with men Serology 03 medical and health sciences Young Adult 0302 clinical medicine Seroepidemiologic Studies Medicine Humans 030212 general & internal medicine Syphilis education Aged education.field_of_study business.industry Coinfection Benzathine/Pénicilline G Antibody titer HIV General Medicine Middle Aged medicine.disease Antibodies Bacterial Anti-Bacterial Agents Penicillin Republic of Chad Titer Infectious Diseases Penicillin G Benzathine Female business medicine.drug |
| Zdroj: | International Journal of Infectious Diseases, Vol 108, Iss, Pp 461-464 (2021) |
| ISSN: | 1878-3511 |
| Popis: | Background Syphilis is endemic in Sub-Saharan zone and disproportionately affect at-risk populations such as of men who have sex with men, sex workers and HIV infected individuals. In this study, we measure the impact of syphilis among people living with HIV in the Republic of Chad, where no data are currently available. Method Outpatients attending in two HIV clinics in N’Djamena, republic of Chad were tested for syphilis. Subjects tested positive for both non-treponemal (VDRL) and treponemal (TPHA) tests received a single dose of benzanthine penicillin G 2.4 million units. An additional VDRL test was performed six months after treatment to ensure appropriate serological response. Results Of 207 patients included, 29 (14%) tested positive for VDLR at the first visit, with moderate/low antibody titers (ranging from ½ to 1/8), and 24 (82.6%) of them had confirmation of treponemal immunization using TPHA. Six months after benzathine penicillin treatment, 22/24 of the patients (91.6%) tested negative for VDLR and two shown a 4-fold titer decline. Conclusion This first study in the Republic of Chad suggests that syphilis infection is frequent among people living with HIV in this country. Systematic screening of syphilis should be considered in this population. |
| Databáze: | OpenAIRE |
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