Flavonoids inhibit angiogenic cytokine production by human glioma cells
| Autor: | Gerson Carvalho, Pedro Rocha Barbosa, Marcienne Bloch Tardy, Roberto Meyer, Silvia Lima Costa, Ivana Nascimento, Robert Eduard Schaer, Sandra Regina Villas Bôas de Freitas, Eudes da Silva Velozo, Songeli Menezes Freire, Camila Azevedo |
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| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Angiogenesis medicine.medical_treatment Angiogenesis Inhibitors Antibodies Monoclonal Humanized Neovascularization chemistry.chemical_compound Internal medicine medicine Humans Flavonoids Pharmacology Neovascularization Pathologic biology Plant Extracts Antibodies Monoclonal Fabaceae biology.organism_classification Dimorphandra mollis Bevacizumab Endothelial stem cell Endocrinology Cytokine chemistry Cell culture Apigenin Casticin Cancer research Cytokines Croton medicine.symptom Glioblastoma Phytotherapy |
| Zdroj: | Phytotherapy Research. 25:916-921 |
| ISSN: | 0951-418X |
| DOI: | 10.1002/ptr.3338 |
| Popis: | VEGF and TGF-β1 are cytokines that stimulate tissue invasion and angiogenesis. These factors are considered as molecular targets for the therapy of glioblastoma. Bevacizumab, a recombinant humanized monoclonal antibody developed against VEGF, inhibits endothelial cell proliferation and vessel formation. Flavonoids obtained from Dimorphandra mollis and Croton betulaster have been described as proliferation inhibitors of a human glioblastoma derived cell line. VEGF and TGF-β1 levels were dosed by ELISA in a GL-15 cell line treated with bevacizumab and also with the flavonoids rutin, 5-hydroxy-7,4'-dimethoxyflavone, casticin, apigenin and penduletin. Rutin reduced the VEGF and TGF-β1 levels after 24 h but not after 72 h. The other flavonoids significantly reduced TGF-β1 production. Bevacizumab reduced only the VEGF levels in the supernatant from GL-15 cultures. These results suggest that the flavonoids studied, and commonly used in popular medicine, present an interesting subject of study due to their potential effect as angiogenic factor inhibitors. |
| Databáze: | OpenAIRE |
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