Glucagon-like peptide-1 preserves coronary microvascular endothelial function after cardiac arrest and resuscitation: potential antioxidant effects
| Autor: | Charles V Piermarini, Betsy B. Dokken, Aeen M Ashgar, Karl B. Kern, Brian D Heller, Jonida Krate, Ronald W. Hilwig, Lauren Querin, Mary K. Teachey, Christian Dameff, Jennifer L Mitchell, Michael Gura |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Resuscitation Antioxidant Endothelium Swine Physiology Heart Ventricles medicine.medical_treatment Incretin Dinoprost Antioxidants Microcirculation Ventricular Dysfunction Left Glucagon-Like Peptide 1 Coronary Circulation Physiology (medical) Internal medicine Animals Humans Medicine Cardiopulmonary resuscitation business.industry Coronary flow reserve Glucagon-like peptide-1 Cardiopulmonary Resuscitation Heart Arrest medicine.anatomical_structure Microvessels Ventricular Fibrillation Cardiology Female Endothelium Vascular Reactive Oxygen Species Cardiology and Cardiovascular Medicine business |
| Zdroj: | American Journal of Physiology-Heart and Circulatory Physiology. 304:H538-H546 |
| ISSN: | 1522-1539 0363-6135 |
| Popis: | Glucagon-like peptide-1 (GLP-1) has protective effects in the heart. We hypothesized that GLP-1 would mitigate coronary microvascular and left ventricular (LV) dysfunction if administered after cardiac arrest and resuscitation (CAR). Eighteen swine were subjected to ventricular fibrillation followed by resuscitation. Swine surviving to return of spontaneous circulation (ROSC) were randomized to receive an intravenous infusion of either human rGLP-1 (10 pmol·kg−1·min−1; n = 8) or 0.9% saline ( n = 8) for 4 h, beginning 1 min after ROSC. CAR caused a decline in coronary flow reserve (CFR) in control animals (pre-arrest, 1.86 ± 0.20; 1 h post-ROSC, 1.3 ± 0.05; 4 h post-ROSC, 1.25 ± 0.06; P < 0.05). GLP-1 preserved CFR for up to 4 h after ROSC (pre-arrest, 1.31 ± 0.17; 1 h post-ROSC, 1.5 ± 0.01; 4 h post-ROSC, 1.55 ± 0.22). Although there was a trend toward improvement in LV relaxation in the GLP-1-treated animals, overall LV function was not consistently different between groups. 8 -iso-PGF2α, a measure of reactive oxygen species load, was decreased in post-ROSC GLP-1-treated animals [placebo, control (NS): 38.1 ± 1.54 pg/ml; GLP-1: 26.59 ± 1.56 pg/ml; P < 0.05]. Infusion of GLP-1 after CAR preserved coronary microvascular and LV diastolic function. These effects may be mediated through a reduction in oxidative stress. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|