Low doses of high-potency antithymocyte globulin (ATG) in severe aplastic anemia: experience with the Mexican ATG
| Autor: | Catalina Taboada, Daniel S. Ruiz-Gonzalez, Vicente Vázquez-Villegas, Antonio Marín-López, Fernando Romero-García, Xavier López-Karpovitch, José Luis Delgado-Lamas, Guillermo J. Ruiz-Argüelles, Maria Elena Zarzosa |
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| Rok vydání: | 1989 |
| Předmět: |
Adult
Male medicine.medical_specialty Every other day Globulin Adolescent medicine.medical_treatment Gastroenterology Drug Administration Schedule Internal medicine medicine Potency Animals Humans Horses Aplastic anemia Child Antilymphocyte Serum Chemotherapy biology business.industry Low dose Remission Induction Complete remission Anemia Aplastic Hematology General Medicine Middle Aged medicine.disease Severe Aplastic Anemia Child Preschool Immunology biology.protein Prednisone Female business |
| Zdroj: | Acta haematologica. 81(2) |
| ISSN: | 0001-5792 |
| Popis: | Twenty patients with severe aplastic anemia (SAA) were treated with low doses (1–5 mg/kg/day) of a high-potency antithymocyte globulin (ATC) produced in Mexico, shown to have at least a 10-fold potency as compared with other globulins of commercial sources. Patients received ATG within a 10-day period, every other day (5 doses) at a dose of 1 mg/kg/day (4 courses), 2 mg/kg/day (12 courses) or 5 mg/kg/day (8 courses). Four patients received 2 consecutive courses of different doses of ATG. A response rate of 42% was recorded in the group, assessed by means of increases in reticulocytes, granulocytes or platelets. One patient showed a complete remission. The 570-day survival of the group was 51 %. It is concluded that the domestically produced ATG is useful in the treatment of some patients with SAA in Mexico. |
| Databáze: | OpenAIRE |
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