Heme oxygenase-1 gene delivery for altering high mobility group box-1 protein in pancreatic islet

Autor:	Min Jun, Kim, Yong Hwa, Hwang, Jin Wook, Hwang, Zahid, Alam, Dong Yun, Lee
Rok vydání:	2022
Předmět:	Islets of Langerhans Mice Calcineurin Islets of Langerhans Transplantation Animals Pharmaceutical Science HMGB1 Protein Poly(ADP-ribose) Polymerase Inhibitors Heme Oxygenase-1 Diabetes Mellitus Experimental
Zdroj:	Journal of Controlled Release. 343:326-337
ISSN:	0168-3659
DOI:	10.1016/j.jconrel.2022.01.031
Popis:	Pancreatic islet transplantation is a promising strategy for the treatment of type I diabetes. High-mobility group box-1 (HMGB1), highly expressed in islet cells, is a potent immune stimulator in immune rejection. Heme oxygenase-1 (HO1) gene therapy can modulate the release of HMGB1 by altering intracellular molecules for successful cell transplantation. After delivery of the heme oxygenase-1 (HO1) gene to islet cells using an adeno-associated viral vector (AAV), it was evaluated the changes in cytoplasmic Ca
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cef80e5f476ca127ee2aec1156e1769f https://doi.org/10.1016/j.jconrel.2022.01.031 Zobrazit plný text záznamu Full Text from ScienceDirect