[Severe hypertriglyceridemia induced by tamoxifen]
| Autor: | Nobuyuki Takasu, Ichiro Komiya, Mika Taira |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Breast Neoplasms chemistry.chemical_compound Breast cancer Internal medicine Hyperlipidemia medicine Humans skin and connective tissue diseases Aged Hypertriglyceridemia Clofibrate Triglyceride business.industry Estrogen Antagonists medicine.disease Tamoxifen Endocrinology chemistry Estrogen Fluorouracil Female Geriatrics and Gerontology business hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics. 35(11) |
| ISSN: | 0300-9173 |
| Popis: | A 71-year-old woman was admitted to our hospital because of severe hypertriglyceridemia. The patient had a 26-year history of non-insulin-dependent diabetes mellitus and hyperlipidemia (T-chol 300 mg/dl, TG 300 mg/dl). She was treated with sulfonylurea and clofibrate. Seven years before admission, she had undergone a radical mastectomy for cancer of the left breast. After the operation, she had received tamoxifen and fluorouracil. One month before admission, she had marked hypertriglyceridemia (triglyceride 2,106 mg/dl). After discontinuation of tamoxifen and fluorouracil, her serum triglyceride level decreased to 372 mg/dl; when tamoxifen was given again, it increased to 581 mg/dl, and her hepatic triglyceride lipase activity decreased from 0.228 to 0.164 mumol FFA/ml/min. Apolipoprotein E phenotype was wild type E3/3. The concentration of sex-hormone-binding globulin increased from 110 to 130 nmol/l. These changes associated with tamoxifen treatment were similar to those seen after administration of estrogen. Tamoxifen, an anti-estrogen, has been used as adjuvant therapy in cases of estrogen-receptor-positive breast cancer. Tamoxifen has some weak estrogenic activity. The tamoxifen-induced hypertriglyceridemia seen in this case was an effect of its estrogenic action. |
| Databáze: | OpenAIRE |
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