Gpr125 is a unifying hallmark of multiple mammary progenitors coupled to tumor latency
| Autor: | Elena Spina, Julia Simundza, Angela Incassati, Anupama Chandramouli, Matthias C. Kugler, Ziyan Lin, Alireza Khodadadi-Jamayran, Christine J. Watson, Pamela Cowin |
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| Přispěvatelé: | Spina, Elena [0000-0002-0838-9466], Kugler, Matthias C [0000-0002-8587-6129], Watson, Christine J [0000-0002-8548-5902], Cowin, Pamela [0000-0002-1827-1154], Apollo - University of Cambridge Repository |
| Rok vydání: | 2022 |
| Předmět: |
49/88
49/22 General Physics and Astronomy Breast Neoplasms General Biochemistry Genetics and Molecular Biology 38/91 631/532/2436 13/1 Mammary Glands Animal 14/34 13/100 Cell Movement Animals Humans 49/90 14/19 49/91 Multidisciplinary Stem Cells article Mammary Neoplasms Experimental General Chemistry 631/67/1347 64/110 631/80/79 13/31 13/51 14/63 38/77 Female 64/60 |
| DOI: | 10.17863/cam.82561 |
| Popis: | Funder: The Susan G Komen Foundation For The Cure Funder: Will-Rogers and the Stony Wold-Herbert Foundation Funder: U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) Funder: NYC Peter Rowley award C02857 Gpr125 is an orphan G-protein coupled receptor, with homology to cell adhesion and axonal guidance factors, that is implicated in planar polarity and control of cell movements. By lineage tracing we demonstrate that Gpr125 is a highly specific marker of bipotent mammary stem cells in the embryo and of multiple long-lived unipotent basal mammary progenitors in perinatal and postnatal glands. Nipple-proximal Gpr125+ cells express a transcriptomic profile indicative of chemo-repulsion and cell movement, whereas Gpr125+ cells concentrated at invasive ductal tips display a hybrid epithelial-mesenchymal phenotype and are equipped to bind chemokine and growth factors and secrete a promigratory matrix. Gpr125 progenitors acquire bipotency in the context of transplantation and cancer and are greatly expanded and massed at the pushing margins of short latency MMTV-Wnt1 tumors. High Gpr125 expression identifies patients with particularly poor outcome within the basal breast cancer subtype highlighting its potential utility as a factor to stratify risk. |
| Databáze: | OpenAIRE |
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