Synchrotron radiation X-ray microtomography for the visualization of intra-cochlear anatomy in human temporal bones implanted with a perimodiolar cochlear implant electrode array
| Autor: | Sara Schneiders, Glynnis De Greve, Lucia Mancini, Fergio Sismono, Jana Goyens, Joris J.J. Dirckx, Bert De Foer, Marc Leblans, Andrzej Zarowski, Karen Beckers |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Nuclear and High Energy Physics Materials science X-ray microtomography medicine.medical_treatment Synchrotron radiation In Vitro Techniques 03 medical and health sciences Imaging Three-Dimensional 0302 clinical medicine Cochlear implant otorhinolaryngologic diseases medicine Electrode array Humans Instrumentation Radiation Physics Contrast resolution Phase-contrast imaging Temporal Bone X-Ray Microtomography Cochlea Electrodes Implanted Visualization Cochlear Implants 030104 developmental biology Electrode Radiographic Image Interpretation Computer-Assisted Synchrotrons 030217 neurology & neurosurgery Biomedical engineering |
| Zdroj: | Journal of synchrotron radiation |
| ISSN: | 1600-5775 0909-0495 |
| Popis: | Recently, synchrotron radiation computed microtomography (SRµCT) has emerged as a promising tool for non-destructive, in situ visualization of cochlear implant electrode arrays inserted into a human cochlea. Histological techniques have been the `gold standard' technique for accurate localization of cochlear implant electrodes but are suboptimal for precise three-dimensional measurements. Here, an SRµCT experimental setup is proposed that offers the benefit of a high spatial and contrast resolution (isotropic voxel size = 4.95 µm and propagation-based phase-contrast imaging), while visualizing the soft-tissue structures and electrode array of the cochlear implant simultaneously. In this work, perimodiolar electrode arrays have been tested, which incorporate thick and closely spaced platinum–iridium contacts and wiring. These data can assist cochlear implant and hearing research, can be used to verify electrode segmentation techniques for clinical computed tomography or could be utilized to evaluate cochlear implant electrode array designs. |
| Databáze: | OpenAIRE |
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