Tel/PDGFRbeta inhibits self-renewal and directs myelomonocytic differentiation of ES cells
| Autor: | Colum P. Walsh, Robin Freeburn, Helen Wheadon, Melanie J. Welham, Edwina Dobbin, Pamela M. Corrigan |
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| Rok vydání: | 2008 |
| Předmět: |
Cancer Research
Oncogene Proteins Fusion Cell Survival Biology Leukemia Inhibitory Factor Mice hemic and lymphatic diseases Gene expression Animals Myeloid Cells Cells Cultured Embryonic Stem Cells Cell Proliferation Myelopoiesis Oncogene Cell Differentiation Hematology Phenotype Molecular biology Embryonic stem cell Cell biology Hematopoiesis Haematopoiesis Oncology Gene Expression Regulation Erythropoiesis Stem cell |
| Zdroj: | Leukemia research. 32(10) |
| ISSN: | 0145-2126 |
| Popis: | The leukemic oncogene Tel/PDGFRbeta, was inducibly expressed in embryonic stem (ES) cells and the phenotypic and molecular changes occurring during hematopoietic differentiation investigated. Expression of Tel/PDGFRbeta resulted in an inability of ES cells to self-renew and caused a significant increase in myelopoiesis with a corresponding decrease in erythropoiesis. Analysis of gene expression patterns indicated a dramatic alteration in the levels of genes associated with self-renewal and differentiation, especially myelomonocytic genes in Tel/PDGFRbeta-expressing cells. This study indicates Tel/PDGFRbeta drives myelopoiesis by altering expression of genes involved in hematopoiesis and demonstrates the potential of this stem cell system to study oncogene-induced pathogenesis. |
| Databáze: | OpenAIRE |
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