Formal substitution of bromocyclopropanes with nitrogen nucleophiles

Autor:	Ivan A. Babkov, Jacob Gentillon, Marina Rubina, Anthony R. Prosser, Pavel Ryabchuk, Michael Rubin, Joseph E. Banning, Andrew J. Edwards, Andrew Holtzen, Andrew Rogers
Rok vydání:	2013
Předmět:	Azoles Cyclopropanes Sulfonamides Aniline Compounds Nucleophile Molecular Structure Chemistry Organic Chemistry Substitution (logic) Organic chemistry Combinatorial chemistry Amides
Zdroj:	The Journal of organic chemistry. 78(15)
ISSN:	1520-6904
Popis:	A highly chemo- and diastereoselective protocol toward amino-substituted donor−acceptor cyclopropanes via the formal nucleophilic displacement in bromocyclopropanes is described. A wide range of N-nucleophiles, including carboxamides, sulfonamides, azoles, and anilines, can be efficiently employed in this transformation, providing expeditious access to stereochemically defined and densely functionalized cyclopropylamine derivatives.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cef141a6289209856e509fc6a1d6e5e3 https://pubmed.ncbi.nlm.nih.gov/23845068 Zobrazit plný text záznamu