Effect of water content in perchloric acid on the non-aqueous potentiometric titration of nitrogen-containing compounds
| Autor: | Robert Jacobus, John Zhang, Xiaohe S Qi, Yoshihiro Namiki, R. Brent Miller |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Clinical Biochemistry
Inorganic chemistry Potentiometric titration Nitro compound Pharmaceutical Science chemistry.chemical_element Analytical Chemistry chemistry.chemical_compound Acetic acid Drug Discovery Perchloric acid Nitrogen Compounds Water content Spectroscopy chemistry.chemical_classification Aqueous solution Chromatography Perchlorates Water Mercury Nitrogen Solutions chemistry Potentiometry Titration Indicators and Reagents |
| Zdroj: | Journal of pharmaceutical and biomedical analysis. 16(3) |
| ISSN: | 0731-7085 |
| Popis: | In the United States Pharmacopeia (USP), 0.1 N perchloric acid in acetic acid volumetric solution (hereafter HClO4 VS) used for non-aqueous titration has specified a water content between 0.02 and 0.05%. Preparing this titrant with such a narrow range of water content is very time consuming, precludes the use of commercially available titrants, and, consequently, prompted an investigation to try and expand the range up to 0.5%. In this study, the titrimetric results obtained using HClO4 VS containing more water were very close to those obtained using the USP specified titrants. A maximum assay difference of 0.7% in the titrations of three selected nitrogen-containing compounds, clonidine hydrochloride, dipyridamole, and adenosine were observed. The titrimetric results obtained using these titrants were also precise with RSDs of not more than 0.4%. Therefore, a wider range of water content in HClO4 VS between 0.02 and 0.5% is suggested for the USP potentiometric titration of nitrogen-containing compounds. |
| Databáze: | OpenAIRE |
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