Simplicilones A and B Isolated from the Endophytic Fungus Simplicillium subtropicum SPC3
| Autor: | Bel Youssouf G. Mountessou, Simeon F. Kouam, Abolfazl Narmani, Frank Surup, Elodie Gisèle M Anoumedem |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Microbiology (medical)
Duguetia staudtii Stereochemistry In vitro cytotoxicity Simplicillium subtropicum Fungus 010402 general chemistry 01 natural sciences Biochemistry Microbiology Duguetia Pharmacology (medical) simplicilones A and B General Pharmacology Toxicology and Pharmaceutics endophytic fungus biology 010405 organic chemistry Chemistry lcsh:RM1-950 Endophytic fungus biology.organism_classification 0104 chemical sciences lcsh:Therapeutics. Pharmacology Infectious Diseases visual_art visual_art.visual_art_medium Bark Simplicillium Two-dimensional nuclear magnetic resonance spectroscopy Bacteria |
| Zdroj: | Antibiotics, Vol 9, Iss 753, p 753 (2020) Antibiotics Volume 9 Issue 11 |
| ISSN: | 2079-6382 |
| DOI: | 10.3390/antibiotics9110753 |
| Popis: | Two new tetracyclic polyketides with a spirocenter, simplicilones A (1) and B (2) were isolated from the broth-culture of the endophytic fungus Simplicilliumsubtropicum (SPC3) in the course of our screening for new bioactive secondary metabolites. This endophytoic fungus is naturally harboured in the fresh bark of the Cameroonian medicinal plant Duguetia staudtii (Engl. and Diels) Chatrou. The planar structures of the simplicilones were elucidated by MS and 1D as well as 2D NMR spectroscopic techniques. The relative configuration was assigned by NOESY experiments in conjunction with coupling constants subsequently, the absolute configurations were assigned by the modified Mosher&rsquo s method. The compounds showed weak cytotoxic effects against the cell line KB3.1 (in vitro cytotoxicity (IC50) = 25 µ g/mL for 1, 29 µ g/mL for 2), but were inactive against the tested Gram-positive and Gram-negative bacteria as well as fungi. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|