Transcriptional reprogramming in cellular quiescence
| Autor: | Benjamin Roche, Benoit Arcangioli, Robert A. Martienssen |
|---|---|
| Přispěvatelé: | Cold Spring Harbor Laboratory (CSHL), Dynamique du Génome - Dynamics of the genome, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Howard Hughes Medical Institute (HHMI), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
dormancy RNA-induced transcriptional silencing Transcription Genetic MESH: Cell Cycle histone Biology Models Biological RNA polymerase III Epigenesis Genetic 03 medical and health sciences RNA interference stem cells [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry Molecular Biology/Genomics [q-bio.GN] Transcriptional regulation G0 quiescence MESH: Epigenesis Genetic Molecular Biology RNA polymerase II holoenzyme Point of View Genetics General transcription factor epigenetics MESH: Transcription Genetic Cell Cycle MESH: Models Biological RNA reprogramming Cell Biology DNA-Directed RNA Polymerases differentiation Non-coding RNA Cell biology MESH: DNA-Directed RNA Polymerases Histone Code RNA silencing 030104 developmental biology MESH: Histone Code transcription Dicer |
| Zdroj: | RNA Biology RNA Biology, Taylor & Francis, 2017, 14 (7), pp.843-853. ⟨10.1080/15476286.2017.1327510⟩ RNA Biology, 2017, 14 (7), pp.843-853. ⟨10.1080/15476286.2017.1327510⟩ |
| ISSN: | 1547-6286 1555-8584 |
| DOI: | 10.1080/15476286.2017.1327510⟩ |
| Popis: | International audience; Most cells in nature are not actively dividing, yet are able to return to the cell cycle given the appropriate environmental signals. There is now ample evidence that quiescent G0 cells are not shut-down but still metabolically and transcriptionally active. Quiescent cells must maintain a basal transcriptional capacity to maintain transcripts and proteins necessary for survival. This implies a tight control over RNA polymerases: RNA pol II for mRNA transcription during G0, but especially RNA pol I and RNA pol III to maintain an appropriate level of structural RNAs, raising the possibility that specific transcriptional control mechanisms evolved in quiescent cells. In accordance with this, we recently discovered that RNA interference is necessary to control RNA polymerase I transcription during G0. While this mini-review focuses on yeast model organisms (Saccharomyces cerevisiae and Schizosaccharomyces pombe), parallels are drawn to other eukaryotes and mammalian systems, in particular stem cells. |
| Databáze: | OpenAIRE |
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