Prognostic results of cisplatin IP and carboplatin IV with G-CSF in patients with ovarian cancer
| Autor: | Kensuke Saito, Yoshio Itani, T. Noda, Kimihiko Ito, Naoto Furukawa, Susumu Adachi, Masafumi Shintani, Yoshihumi Tomii |
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| Rok vydání: | 2001 |
| Předmět: |
Oncology
Cancer Research medicine.medical_treatment Cystadenocarcinoma Mucinous Carboplatin chemistry.chemical_compound Japan Antineoplastic Combined Chemotherapy Protocols Granulocyte Colony-Stimulating Factor Life Tables Infusions Intravenous Ovarian Neoplasms General Medicine Middle Aged Prognosis Treatment Outcome Child Preschool Female Carcinoma Endometrioid Injections Intraperitoneal medicine.drug Adult medicine.medical_specialty Adenocarcinoma Disease-Free Survival Drug Administration Schedule Internal medicine medicine Carcinoma Humans Survival rate Aged Cisplatin Chemotherapy business.industry Cancer medicine.disease Hematologic Diseases Survival Analysis Cystadenocarcinoma Serous Surgery Regimen chemistry business Ovarian cancer Adenocarcinoma Clear Cell Follow-Up Studies |
| Zdroj: | Oncology Reports. |
| ISSN: | 1791-2431 1021-335X |
| Popis: | We performed a dose-escalation study of carboplatin combined with a fixed dose of intraperitoneal cisplatin and G-CSF in patients with epithelial ovarian cancer, and analyzed the progression-free and overall survival. Six of the patients who entered the study with stage IC and II disease are still alive with no evidence of disease. The five-year survival rate was 61% for the 18 patients with stage III and IV disease; progression-free survival over 5 years was 32%. Our results show this to be an effective treatment regimen for epithelial ovarian cancer. Prognosis is good with this combined carboplatin/cisplatin/G-CSF therapy, especially for those patients with microscopic or no residual disease. |
| Databáze: | OpenAIRE |
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