T-cell phenotypic profiles in the cerebrospinal fluid and peripheral blood of multiple sclerosis patients
| Autor: | Luisa Caniatti, Diana Degani, Maria Rosaria Tola, R. Scolozzi, Ezio Paolino, A. Camerani, Boccafogli A, Enrico Granieri, Vicentini L |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
CD4-Positive T-Lymphocytes Male Multiple Sclerosis Adolescent medicine.drug_class T cell Cell CD16 Monoclonal antibody cerebrospinal fluid CD19 T-cell phenotype Cerebrospinal fluid T-Lymphocyte Subsets medicine Humans Lymphocytes Aged Multiple sclerosis Inflammation biology business.industry Antibodies Monoclonal Receptors Interleukin-2 HLA-DR Antigens Middle Aged medicine.disease medicine.anatomical_structure Neurology Immunology biology.protein Female Neurology (clinical) Nervous System Diseases business CD8 |
| Zdroj: | Journal of the Neurological Sciences. 108:93-98 |
| ISSN: | 0022-510X |
| DOI: | 10.1016/0022-510x(92)90193-o |
| Popis: | Thirty-nine patients with clinically definite multiple sclerosis (MS) entered the study. Of 28 subjects with a relapsing-remitting course, 19 were classified in acute relapse, 9 in remission; 11 patients had a progressive course without remissions. Furthermore, 6 subjects with inflammatory neurological disease (IND), and 10 with non-inflammatory and non-neoplastic neurological disease (NIND) were investigated. We simultaneously studied cerebrospinal fluid (CSF) and peripheral blood (PB) T-, B- and NK-cell subsets, as defined by following monoclonal antibodies: anti-CD3, -CD4, -CD8, -CD19, -CD16, -HLA-DR and -IL-2-R. We found a significant increase of CD4+T-cells compared with controls in CSF, with respect to PB, of MS patients, particularly in acute relapse. An increase of HLA-DR + cell percentages in the CSF than in the PB in all MS groups, especially in attacks of MS but also in remission, was also observed, with a positive correlation between CD4 + T-cell and DR + cell percentages both in the CSF as well as in the PB of relapsing MS patients. These findings, together with the increase of IL-2-R + cells in the PB, particularly in relapsing MS, give further support for the presence of a systemic T-cell activation in MS. |
| Databáze: | OpenAIRE |
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