Effect of isolated vitamin D supplementation on bone turnover markers in younger postmenopausal women: a randomized, double-blind, placebo-controlled trial
| Autor: | Claudio Lera Orsatti, Priscila Ferreira Poloni, Flávia Neves Bueloni-Dias, Eneida Boteon Schmitt, Eliana Aguiar Petri Nahás, Luciana Mendes Cangussu, Jorge Nahas-Neto |
|---|---|
| Přispěvatelé: | Universidade Estadual Paulista (Unesp) |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Vitamin
medicine.medical_specialty Bone turnover Endocrinology Diabetes and Metabolism Placebo-controlled study 030209 endocrinology & metabolism Bone resorption Bone remodeling 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine N-terminal telopeptide Double-Blind Method Internal medicine medicine Vitamin D and neurology Humans 030212 general & internal medicine Vitamin D Aged Cholecalciferol business.industry Middle Aged medicine.disease Alkaline Phosphatase Vitamin D Deficiency Menopause Postmenopause Endocrinology chemistry Parathyroid Hormone Dietary Supplements Alkaline phosphatase Calcium Female Bone Remodeling business Biomarkers |
| Zdroj: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| Popis: | Made available in DSpace on 2018-12-11T17:18:01Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-05-01 Summary: Vitamin D (VD) plays an important role in bone mineralization. The present study investigates the effect of VD supplementation alone on bone turnover markers in younger postmenopausal women. It has been shown that VD supplementation in postmenopausal women with hypovitaminosis D is associated with a reduction in bone turnover markers. Purpose: The purpose of this study is to evaluate the effect of VD supplementation alone on bone turnover markers in younger postmenopausal women. Methods: In this double-blind, placebo-controlled trial, 160 women were randomized into the VD group (supplementation with 1000 IU of vitamin D3/day, orally; n = 80) or placebo group (n = 80). Women aged 50–65 years with amenorrhea ≥ 12 months and normal bone mineral density were included. The intervention lasted 9 months, and the participants were assessed at the beginning and end of treatment. Serum levels of total calcium, parathormone (PTH), alkaline phosphatase (AP), and 24-h urine calcium were determined. Serum C-terminal telopeptide of type I collagen (s-CTX) and procollagen type 1 N-terminal propeptide (P1NP) were measured by immunoassay as markers of bone resorption and formation, respectively. Plasma 25-hydroxyvitamin-D [25(OH)D] concentrations were measured by HPLC. Intention-to-treat analysis was performed using ANOVA, Student’s t test, Tukey’s test, and gamma distribution. Results: Over the period of 9 months, 25(OH)D concentrations increased from 15.0 ± 7.5 to 27.5 ± 10.4 ng/mL (+ 45.4%) in the VD group and decreased from 16.9 ± 6.7 to 13.8 ± 6.0 ng/mL (− 18.5%) in the placebo group (p < 0.001). There was a decrease (− 21.3%) of PTH levels in the VD group with a significant difference between groups at the end of the study (p < 0.001). No significant differences were observed in the other laboratory parameters (total calcium, AP, and calciuria) in either group (p > 0.05). A comparison of bone turnover markers showed a significant reduction in of s-CTX (− 24.2%, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|