The association between plasma cholesterol and the effect of tryptophan depletion on heart rate variability
| Autor: | I. Hui Lee, Po See Chen, Kao Chin Chen, Yen Kuang Yang, Wei Hung Chang, Shih Hsien Lin, Mei Hung Chi, Hsin Chun Tsai |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Blood lipids tryptophan depletion Anxiety 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine High-density lipoprotein Heart Rate Internal medicine Heart rate Medicine Heart rate variability Humans lcsh:R5-920 affective disorder business.industry Cholesterol Depression Cholesterol HDL autonomic nervous system Tryptophan cholesterol General Medicine Cholesterol LDL Middle Aged medicine.disease serotonin Autonomic nervous system Endocrinology chemistry Mood disorders 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology Female lipids (amino acids peptides and proteins) Serotonin business lcsh:Medicine (General) |
| Zdroj: | Kaohsiung Journal of Medical Sciences, Vol 35, Iss 7, Pp 440-445 (2019) |
| ISSN: | 2410-8650 |
| Popis: | Studies on the cholesterol‐serotonin hypothesis and its link to mood disorders are scarce. In addition, little is known about the association between cholesterol and the effects of tryptophan depletion (TD). The aim of the present study was to investigate the association between plasma cholesterol and changes in heart rate variability (HRV), an important marker of depression and anxiety, after TD. The plasma cholesterol levels of 28 healthy participants were noted, and their HRVs were measured by spectrum analysis. TD was carried out on testing day, and participants provided blood samples just before and 5 hours for tryptophan level after TD. HRV was measured again after TD. An association was found between plasma cholesterol levels and the change in HRV. Decreased high frequency HRV was marginally associated with lower levels of high‐density lipoprotein cholesterol, while increased low frequency HRV was significantly associated with lower levels of total and low‐density lipoprotein cholesterol. Our findings indicate that low cholesterol levels may play parts of role in the mechanism of the deactivation of parasympathetic, and activation of sympathetic, functions induced by altered serotonergic function. |
| Databáze: | OpenAIRE |
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