Inflammation and Prolonged QT Time: Results from the Cardiovascular Disease, Living and Ageing in Halle (CARLA) Study

Autor: Harald Loppnow, Karin Halina Greiser, Johannes Haerting, Daniel Medenwald, Alexander Kluttig, Daniel Tiller, Karl Werdan, Joachim Thiery, Jan A. Kors, Sebastian Nuding
Přispěvatelé: Medical Informatics
Rok vydání: 2014
Předmět:
Male
Aging
Urban Population
Physiology
Epidemiology
Cross-sectional study
lcsh:Medicine
Logistic regression
Cohort Studies
Cardiac Conduction System Disease
Heart Rate
Germany
Medicine and Health Sciences
lcsh:Science
Brugada Syndrome
Aged
80 and over
education.field_of_study
Multidisciplinary
Confounding
Atrial fibrillation
Middle Aged
Electrophysiology
Receptors
Tumor Necrosis Factor
Type I
Research Design
Cohort
Female
Inflammation Mediators
Research Article
medicine.medical_specialty
Clinical Research Design
Population
Cardiology
Research and Analysis Methods
SDG 3 - Good Health and Well-being
Heart Conduction System
Internal medicine
medicine
Humans
education
Aged
Interleukin-6
Tumor Necrosis Factor-alpha
business.industry
lcsh:R
Biology and Life Sciences
Arrhythmias
Cardiac
Odds ratio
medicine.disease
Confidence interval
Biomarker Epidemiology
Cross-Sectional Studies
Immunology
Linear Models
lcsh:Q
business
Zdroj: PLoS One (print), 9(4). Public Library of Science
PLoS ONE, Vol 9, Iss 4, p e95994 (2014)
PLoS ONE
ISSN: 1932-6203
Popis: textabstractBackground: Previous research found an association of CRP with QT time in population based samples. Even more, there is evidence of a substantial involvement of the tumor necrosis factor-alpha system in the pathophysiology of cardiac arrhythmia, while the role of Interleukin 6 remains inconclusive. Objective: To determine the association between inflammation with an abnormally prolonged QT-time (APQT) in men and women of the elderly general population. Methods: Data descend from the baseline examination of the prospective, population-based Cardiovascular Disease, Living and Ageing in Halle (CARLA) Study. After exclusion of subjects with atrial fibrillation and missing ECG recording the final study cohort consisted of 919 men and 797 women. Blood parameters of inflammation were the soluble TNF-Receptor 1 (sTNF-R1), the high-sensitive C-reactive protein (hsCRP), and Interleukin 6 (IL-6). In accordance with major cardiologic societies we defined an APQT above a QT time of 460 ms in women and 450 ms in men. Effect sizes and the corresponding 95% confidence intervals (CI) were estimated by performing multiple linear and logistic regression analyses including the analysis of sex differences by interaction terms. Results: After covariate adjustment we found an odds ratio (OR) of 1.89 (95% CI: 1.13, 3.17) per 1000 pg/mL increase of sTNF-R1 in women, and 0.74 (95% CI: 0.48, 1.15) in men. In the covariate adjusted linear regression sTNF-R1 was again positively associated with QT time in women (5.75 ms per 1000 pg/mL, 95% CI: 1.32, 10.18), but not in men. Taking possible confounders into account IL-6 and hsCRP were not significantly related to APQT in both sexes. Conclusion: Our findings from cross-sectional analyses give evidence for an involvement of TNF-alpha in the pathology of APQT in women.
Databáze: OpenAIRE
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