Inflammation and Prolonged QT Time: Results from the Cardiovascular Disease, Living and Ageing in Halle (CARLA) Study
Autor: | Harald Loppnow, Karin Halina Greiser, Johannes Haerting, Daniel Medenwald, Alexander Kluttig, Daniel Tiller, Karl Werdan, Joachim Thiery, Jan A. Kors, Sebastian Nuding |
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Přispěvatelé: | Medical Informatics |
Rok vydání: | 2014 |
Předmět: |
Male
Aging Urban Population Physiology Epidemiology Cross-sectional study lcsh:Medicine Logistic regression Cohort Studies Cardiac Conduction System Disease Heart Rate Germany Medicine and Health Sciences lcsh:Science Brugada Syndrome Aged 80 and over education.field_of_study Multidisciplinary Confounding Atrial fibrillation Middle Aged Electrophysiology Receptors Tumor Necrosis Factor Type I Research Design Cohort Female Inflammation Mediators Research Article medicine.medical_specialty Clinical Research Design Population Cardiology Research and Analysis Methods SDG 3 - Good Health and Well-being Heart Conduction System Internal medicine medicine Humans education Aged Interleukin-6 Tumor Necrosis Factor-alpha business.industry lcsh:R Biology and Life Sciences Arrhythmias Cardiac Odds ratio medicine.disease Confidence interval Biomarker Epidemiology Cross-Sectional Studies Immunology Linear Models lcsh:Q business |
Zdroj: | PLoS One (print), 9(4). Public Library of Science PLoS ONE, Vol 9, Iss 4, p e95994 (2014) PLoS ONE |
ISSN: | 1932-6203 |
Popis: | textabstractBackground: Previous research found an association of CRP with QT time in population based samples. Even more, there is evidence of a substantial involvement of the tumor necrosis factor-alpha system in the pathophysiology of cardiac arrhythmia, while the role of Interleukin 6 remains inconclusive. Objective: To determine the association between inflammation with an abnormally prolonged QT-time (APQT) in men and women of the elderly general population. Methods: Data descend from the baseline examination of the prospective, population-based Cardiovascular Disease, Living and Ageing in Halle (CARLA) Study. After exclusion of subjects with atrial fibrillation and missing ECG recording the final study cohort consisted of 919 men and 797 women. Blood parameters of inflammation were the soluble TNF-Receptor 1 (sTNF-R1), the high-sensitive C-reactive protein (hsCRP), and Interleukin 6 (IL-6). In accordance with major cardiologic societies we defined an APQT above a QT time of 460 ms in women and 450 ms in men. Effect sizes and the corresponding 95% confidence intervals (CI) were estimated by performing multiple linear and logistic regression analyses including the analysis of sex differences by interaction terms. Results: After covariate adjustment we found an odds ratio (OR) of 1.89 (95% CI: 1.13, 3.17) per 1000 pg/mL increase of sTNF-R1 in women, and 0.74 (95% CI: 0.48, 1.15) in men. In the covariate adjusted linear regression sTNF-R1 was again positively associated with QT time in women (5.75 ms per 1000 pg/mL, 95% CI: 1.32, 10.18), but not in men. Taking possible confounders into account IL-6 and hsCRP were not significantly related to APQT in both sexes. Conclusion: Our findings from cross-sectional analyses give evidence for an involvement of TNF-alpha in the pathology of APQT in women. |
Databáze: | OpenAIRE |
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