Life without brain serotonin: Reevaluation of serotonin function with mice deficient in brain serotonin synthesis
| Autor: | Susann Matthes, Valentina Mosienko, Natalia Alenina, Massimo Pasqualetti, Daniel Beis, Fatimunnisa Qadri, Michael Bader, Jonas Waider |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Serotonin
medicine.medical_specialty Tryptophan Hydroxylase Serotonergic Behavioral Neuroscience chemistry.chemical_compound Internal medicine medicine Animals Humans Neurotransmitter Serotonin transporter 5-HT receptor Behavior Animal biology TPH2 Brain Tryptophan hydroxylase Disease Models Animal Endocrinology Monoamine neurotransmitter chemistry Receptors Serotonin biology.protein Neuroscience |
| Popis: | Tryptophan hydroxylase (TPH) is a rate limiting enzyme in the synthesis of serotonin (5-HT), a monoamine which works as an autacoid in the periphery and as a neurotransmitter in the central nervous system. In 2003 we have discovered the existence of a second Tph gene, which is expressed exclusively in the brain, and, therefore, is responsible for the 5-HT synthesis in the central nervous system. In the following years several research groups have independently generated Tph2-deficient mice. In this review we will summarize the data gained from the existing mouse models with constitutive or conditional deletion of the Tph2 gene, focusing on biochemical, developmental, and behavioral consequences of Tph2-deficiency. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|