Structural influences on intracellular cadmium mobilization by dithiols
| Autor: | Loretta M. Atkins, Mark M. Jones, Gale Gr, Alayne B. Smith, Pramod K. Singh |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
Cadmium Cadmium Poisoning Stereochemistry Xylene chemistry.chemical_element Dithiol General Medicine Toxicology chemistry.chemical_compound Mice Structure-Activity Relationship chemistry In vivo Toxicity Molecule Animals Body Burden Chelation Tissue Distribution Sulfhydryl Compounds Intracellular Chelating Agents |
| Zdroj: | Toxicology letters. 54(2-3) |
| ISSN: | 0378-4274 |
| Popis: | An examination of 5 dithiols, N -(2,3-dimercaptopropyl)phthalamidic acid (DMPA), benzene-1,2-dithiol (BDT), toluene-3,4-dithiol (TDT), α , α '-dimercapto- o -xylene (DOX), and 4,5-dimethyl- α , α '-dimercapto- o -xylene (DDOX), reveals that these compounds are all inferior to previously reported compounds as agents for the in vivo mobilization of cadmium from its intracellular sites, although all possess sulfhydryl groups capable of reacting with cadmium. The results demonstrate the considerable importance of those parts of the molecule which do not participate directly in the formation of chelate rings in the determination of the ultimate behavior of such compounds in vivo. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|