Quality assessment of meta-analyses evaluating randomized clinical trials to improve the prognosis of septic shock: an overview of systematic reviews
| Autor: | Vicente Francisco Gil-Guillén, Antonio Palazón-Bru, Concepción Beneyto-Ripoll, Ana María Martínez-Díaz, Patricia Llópez-Espinós, María de Los Ángeles Carbonell-Torregrosa |
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| Rok vydání: | 2020 |
| Předmět: |
Research Report
medicine.medical_specialty MEDLINE 030204 cardiovascular system & hematology law.invention 03 medical and health sciences 0302 clinical medicine Meta-Analysis as Topic Randomized controlled trial law Surveys and Questionnaires medicine Humans Routine clinical practice 030212 general & internal medicine Intensive care medicine Randomized Controlled Trials as Topic Quality assessment business.industry Septic shock General Medicine Prognosis medicine.disease Shock Septic Clinical trial Systematic review business |
| Zdroj: | Current Medical Research and Opinion. 36:929-939 |
| ISSN: | 1473-4877 0300-7995 |
| DOI: | 10.1080/03007995.2020.1754188 |
| Popis: | Objective: Clinical guidelines for the treatment of septic shock are based on the studies with the best scientific evidence, which are meta-analyses of clinical trials. However, these meta-analyses may have methodological limitations that prevent their conclusions from being extrapolated to routine clinical practice. Therefore, the objective of this study is to determine the quality of these meta-analyses through a systematic review.Methods: In this systematic review, we searched MEDLINE, Scopus and EMBASE from inception to May 2019. We selected meta-analyses from clinical trials that determined the effectiveness of an intervention in reducing the incidence of mortality in patients with septic shock. All items were extracted from the Overview Quality Assessment Questionnaire (OQAQ), which collects information from both systematic reviews and meta-analyses.Results: A total of 34 studies were included. Most elements of the OQAQ were conducted satisfactorily, although 35.3% of meta-analyses did not use a quality assessment of the studies included in other analyses. In 52.9% of meta-analyses, the quality of the studies was high or very high.Conclusions: The methods used to obtain the results should be taken into account when recommending an intervention to treat septic shock if the evidence comes from a meta-analysis of the analyzed characteristics. |
| Databáze: | OpenAIRE |
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