Genome-wide integrative analysis revealed a correlation between lengths of copy number segments and corresponding gene expression profile
| Autor: | Hiroyuki Uetake, Kenichi Sugihara, Mahmut Yasen, Hiroshi Mizushima, Hiroshi Tanaka, Toshiaki Ishikawa, Shigeki Arii, Ken Miyaguchi, Yutaka Fukuoka, Shota Nemoto, Shinji Tanaka |
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| Rok vydání: | 2011 |
| Předmět: |
copy number alteration
Microarray business.industry Microarray analysis techniques Cancer hepatocellular carcinoma General Medicine Hypothesis medicine.disease_cause Bioinformatics medicine.disease Genome Molecular biology digestive system diseases Metastasis colorectal carcinoma Gene expression gene expression medicine Carcinogenesis business microarray Gene |
| Zdroj: | Bioinformation |
| ISSN: | 0973-2063 0973-8894 |
| Popis: | Microarray analysis has been applied to comprehensively reveal the abnormalities of DNA copy number (CN) and gene expression in human cancer research during the last decade. These analyses have individually contributed to identify the genes associated with carcinogenesis, progression, metastasis of tumor cells and poor prognosis of cancer patients. However, it is known that the correlation between profiles of CN and gene expression does not highly correlate. Factors which determine the degree of correlation remain largely unexplained. To investigate one such factor, we performed trend analyses between the lengths of CN segments and corresponding gene expression profiles from microarray data in hepatocellular carcinoma (HCC) and colorectal carcinoma (CRC). Significant correlations were observed in CN gain of HCC and CRC (p |
| Databáze: | OpenAIRE |
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