Evaluation of Intraductal Ultrasonography, Endoscopic Brush Cytology and K-ras, P53 Gene Mutation in the Early Diagnosis of Malignant Bile Duct Stricture
| Autor: | Xiao Zhang, Wen Lyu, Hao Zhang, Zhen Fan, Ping Huang, Xiaofeng Zhang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty lcsh:Medicine Bile Duct Neoplasm Bile Duct Diseases Constriction Pathologic Gene mutation Gastroenterology P53 Gene Mutations Metastasis Internal medicine mental disorders medicine Bile duct stenosis Humans K-ras Brush Cytology Intraductal Ultrasonography Malignant Biliary Stricture Aged Aged 80 and over Bile duct business.industry Brush cytology lcsh:R General Medicine Middle Aged medicine.disease Genes p53 Intraductal ultrasonography medicine.anatomical_structure Genes ras Bile Duct Neoplasms Mutation Original Article Female Bile Ducts business |
| Zdroj: | Chinese Medical Journal Chinese Medical Journal, Vol 128, Iss 14, Pp 1887-1892 (2015) |
| ISSN: | 0366-6999 |
| Popis: | Background: In qualitative diagnosis of bile duct stenosis, single diagnostic measure is difficult to make a correct diagnosis, to combine several diagnostic techniques may be helpful to make an accurate diagnosis. The aim of this study was to evaluate the value of intraductal ultrasonography (IDUS), endoscopic brush cytology and K-ras, P53 gene mutation in the early diagnosis of malignant biliary stricture. Methods: From February 2012 to February 2013, 84 patients with suspected malignant biliary stricture were performed IDUS firstly, then endoscopic brush cytology and finally K-ras, P53 gene mutation detection, the sensitivity, specificity, positive predictive value, negative predictive value and accuracy of all above ways were evaluated and compared. Results: Of 84 patients, 52 cases were ultimately diagnosed malignant biliary stenosis; of which, 9 cases had no recurrence or metastasis to other organs after radical operation during the follow-up period. IDUS combined with brush cytology and K-ras + P53 gene mutation detection had obvious advantage in the sensitivity, accuracy and negative predictive value than any other joint detection and single detection (the advantage was more significant compared with IDUS + brush cytology or any single detection P < 0.01). There were obvious statistical significance in the sensitivity and accuracy between IDUS + brush cytology + P53 or IDUS + brush cytology + K-ras and IDUS + brush cytology or IDUS (P < 0.05). There was no statistical significance in the sensitivity, specificity, positive predictive value, negative predictive value and accuracy between IDUS + brush cytology + P53 and IDUS + brush cytology + K-ras (P > 0.05). Conclusions: IDUS combined with brush cytology and K-ras, P53 gene mutation detection is better than the separate detection and contribute to the early diagnosis of malignant biliary stricture. Its more widespread use is recommended. |
| Databáze: | OpenAIRE |
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